Assay Detail
Binding
CHEMBL1614082
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Counterscreen for inhibitors of tRNA 2'-phosphotransferase (TPT1): fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors of RNAse T1. (Class of assay: confirmatory) [Related pubchem assays: 1963 (Summary AID.), 1962 (Primary screen (TPT1 inhibitors).), 2153 (Counterscreen (RNase inhibitors).), 2149 (Confirmation screen (TPT1 inhibitors).)]
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aspergillus oryzae |
| Category | confirmatory |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Guanyl-specific ribonuclease T1 (CHEMBL1075043) ↗| Type | SINGLE PROTEIN |
| Organism | Aspergillus oryzae (strain ATCC 42149 / RIB 40) |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.22 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1431007 | — | — | 1 | 6.62 |
| CHEMBL1517376 | — | — | 1 | 5.67 |
| CHEMBL1464805 | — | — | 1 | 5.14 |
| CHEMBL1517227 | — | — | 1 | 5.11 |
| CHEMBL257359 | — | — | 1 | 5.01 |
| CHEMBL1401747 | — | — | 1 | 4.91 |
| CHEMBL1416439 | — | — | 1 | 4.73 |
| CHEMBL1611294 | — | — | 1 | 4.55 |
| CHEMBL1458563 | — | — | 1 | - |
| CHEMBL1988133 | — | — | 1 | - |
| CHEMBL1990545 | — | — | 1 | - |
| CHEMBL1460470 | — | — | 1 | - |
| CHEMBL1590946 | CEFSULODIN SODIUM | -1.0 | 1 | - |
| CHEMBL1497651 | — | — | 1 | - |
| CHEMBL1455226 | — | — | 1 | - |
| CHEMBL3197767 | — | — | 1 | - |
| CHEMBL6246 | ELLAGIC ACID | 2.0 | 1 | - |
| CHEMBL1329141 | — | — | 1 | - |
| CHEMBL1322297 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1431007 | — | IC50 | = | 237.68 | nM | 6.62 |
| CHEMBL1517376 | — | IC50 | = | 2133.0 | nM | 5.67 |
| CHEMBL1464805 | — | IC50 | = | 7177.0 | nM | 5.14 |
| CHEMBL1517227 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL257359 | — | IC50 | = | 9846.0 | nM | 5.01 |
| CHEMBL1401747 | — | IC50 | = | 12276.0 | nM | 4.91 |
| CHEMBL1416439 | — | IC50 | = | 18474.0 | nM | 4.73 |
| CHEMBL1611294 | — | IC50 | = | 28034.0 | nM | 4.55 |
| CHEMBL1458563 | — | IC50 | > | 55688.0 | nM | - |
| CHEMBL1988133 | — | IC50 | > | 55688.0 | nM | - |
| CHEMBL1990545 | — | IC50 | > | 55688.0 | nM | - |
| CHEMBL1460470 | — | IC50 | > | 55688.0 | nM | - |
| CHEMBL1590946 | CEFSULODIN SODIUM | IC50 | > | 55688.0 | nM | - |
| CHEMBL1497651 | — | IC50 | > | 55688.0 | nM | - |
| CHEMBL1455226 | — | IC50 | > | 55688.0 | nM | - |
| CHEMBL3197767 | — | IC50 | > | 55688.0 | nM | - |
| CHEMBL6246 | ELLAGIC ACID | IC50 | > | 55688.0 | nM | - |
| CHEMBL1329141 | — | IC50 | > | 55688.0 | nM | - |
| CHEMBL1322297 | — | IC50 | > | 55688.0 | nM | - |