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Assay Detail

CHEMBL1909084

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
DRUGMATRIX: Sodium/nucleoside co-transporter radioligand binding (ligand: nitrobenzylthioinosine)
ChEMBL ↗
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Tissue Cerebral cortex
Subcellular Membrane
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

DrugMatrix in vitro pharmacology data
Scott S. Auerbach, DrugMatrix¨ and ToxFX¨ Coordinator National Toxicology Program

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 871 5.22 7.08
Ki 871 5.69 7.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL932 DIPYRIDAMOLE 4.0 2 7.54
CHEMBL413 SIROLIMUS 4.0 2 6.43
CHEMBL1428 NIMODIPINE 4.0 2 6.36
CHEMBL157101 KETOCONAZOLE 4.0 2 5.82
CHEMBL635 PREDNISONE 4.0 2 5.77
CHEMBL10 SB-203580 — 2 5.69
CHEMBL1714574 TERCONAZOLE 4.0 2 5.37
CHEMBL411 DIETHYLSTILBESTROL 4.0 2 5.32
CHEMBL296419 ASTEMIZOLE 4.0 2 5.31
CHEMBL960 LEFLUNOMIDE 4.0 2 5.29
CHEMBL964 DISULFIRAM 4.0 2 5.24
CHEMBL1909069 — — 2 5.21
CHEMBL103 PROGESTERONE 4.0 2 5.17
CHEMBL193 NIFEDIPINE 4.0 2 5.09
CHEMBL264374 BEZAFIBRATE 3.0 2 -
CHEMBL415690 BETADEX 3.0 2 -
CHEMBL31184 BENZO[DEF]CHRYSENE 0.5 2 -
CHEMBL1598608 AZASETRON 2.0 2 -
CHEMBL24 ATENOLOL 4.0 2 -
CHEMBL277474 ANTIPYRINE 3.0 2 -
CHEMBL44814 CARBON TETRACHLORIDE -1.0 2 -
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER — 2 -
CHEMBL894 BUPROPION 4.0 2 -
CHEMBL1077 BROMFENAC 4.0 2 -
CHEMBL3084803 ASTROMICIN 2.0 2 -
CHEMBL1231530 BETAMIPRON 2.0 2 -
CHEMBL12089 BERBERINE CHLORIDE 1.0 2 -
CHEMBL221753 BENZETHONIUM CHLORIDE 2.0 2 -
CHEMBL701 BACLOFEN 4.0 2 -
CHEMBL1095699 AZASERINE 2.0 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL932 DIPYRIDAMOLE Ki = 29.0 nM 7.54
CHEMBL932 DIPYRIDAMOLE IC50 = 83.0 nM 7.08
CHEMBL413 SIROLIMUS Ki = 371.1 nM 6.43
CHEMBL1428 NIMODIPINE Ki = 433.0 nM 6.36
CHEMBL413 SIROLIMUS IC50 = 1084.8 nM 5.96
CHEMBL1428 NIMODIPINE IC50 = 1266.0 nM 5.90
CHEMBL157101 KETOCONAZOLE Ki = 1510.0 nM 5.82
CHEMBL635 PREDNISONE Ki = 1692.0 nM 5.77
CHEMBL10 SB-203580 Ki = 2026.0 nM 5.69
CHEMBL1714574 TERCONAZOLE Ki = 4236.0 nM 5.37
CHEMBL157101 KETOCONAZOLE IC50 = 4412.0 nM 5.36
CHEMBL411 DIETHYLSTILBESTROL Ki = 4833.0 nM 5.32
CHEMBL635 PREDNISONE IC50 = 4947.0 nM 5.31
CHEMBL296419 ASTEMIZOLE Ki = 4876.0 nM 5.31
CHEMBL960 LEFLUNOMIDE Ki = 5159.0 nM 5.29
CHEMBL964 DISULFIRAM Ki = 5788.0 nM 5.24
CHEMBL10 SB-203580 IC50 = 5923.0 nM 5.23
CHEMBL1909069 — Ki = 6109.0 nM 5.21
CHEMBL103 PROGESTERONE Ki = 6703.0 nM 5.17
CHEMBL193 NIFEDIPINE Ki = 8153.0 nM 5.09
CHEMBL1714574 TERCONAZOLE IC50 = 12383.0 nM 4.91
CHEMBL411 DIETHYLSTILBESTROL IC50 = 14126.0 nM 4.85
CHEMBL296419 ASTEMIZOLE IC50 = 14252.0 nM 4.85
CHEMBL960 LEFLUNOMIDE IC50 = 15081.0 nM 4.82
CHEMBL964 DISULFIRAM IC50 = 16918.0 nM 4.77
CHEMBL1909069 — IC50 = 17856.0 nM 4.75
CHEMBL103 PROGESTERONE IC50 = 19593.0 nM 4.71
CHEMBL193 NIFEDIPINE IC50 = 23832.0 nM 4.62
CHEMBL1221512 — IC50 - — -
CHEMBL1201193 LEVOBUPIVACAINE IC50 - — -
CHEMBL480 LANSOPRAZOLE IC50 - — -
CHEMBL480 LANSOPRAZOLE Ki - — -
CHEMBL1221512 — Ki - — -
CHEMBL1373 MODAFINIL Ki - — -
CHEMBL1373 MODAFINIL IC50 - — -
CHEMBL1201151 MESTRANOL Ki - — -
CHEMBL1201151 MESTRANOL IC50 - — -
CHEMBL1201139 MEGESTROL ACETATE Ki - — -
CHEMBL1201139 MEGESTROL ACETATE IC50 - — -
CHEMBL1909067 — Ki - — -
CHEMBL1909067 — IC50 - — -
CHEMBL503 LOVASTATIN Ki - — -
CHEMBL503 LOVASTATIN IC50 - — -
CHEMBL1909064 LIPOPOLYSACCHARIDE E. COLI O55:B5 Ki - — -
CHEMBL1909064 LIPOPOLYSACCHARIDE E. COLI O55:B5 IC50 - — -
CHEMBL1201237 LEVOBUNOLOL Ki - — -
CHEMBL1201237 LEVOBUNOLOL IC50 - — -
CHEMBL741 LAMOTRIGINE Ki - — -
CHEMBL6437 MIANSERIN Ki - — -
CHEMBL741 LAMOTRIGINE IC50 - — -