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Assay Detail

CHEMBL1909154

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
DRUGMATRIX: Glutamate, NMDA, Phencyclidine radioligand binding (ligand: [3H] TCP)
ChEMBL ↗
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Cerebral cortex
Subcellular Membrane
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

DrugMatrix in vitro pharmacology data
Scott S. Auerbach, DrugMatrix¨ and ToxFX¨ Coordinator National Toxicology Program

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 871 5.37 6.00
Ki 871 5.54 6.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL742 KETAMINE 4.0 2 6.17
CHEMBL52440 DEXTROMETHORPHAN 4.0 2 5.79
CHEMBL660 AMANTADINE 4.0 2 4.66
CHEMBL1487 ATORVASTATIN 4.0 2 -
CHEMBL1256017 ARCAINE SULFATE — 2 -
CHEMBL113 CAFFEINE 4.0 2 -
CHEMBL49 BUSPIRONE 4.0 2 -
CHEMBL253376 BROMHEXINE 3.0 2 -
CHEMBL108 CARBAMAZEPINE 4.0 2 -
CHEMBL264374 BEZAFIBRATE 3.0 2 -
CHEMBL415690 BETADEX 3.0 2 -
CHEMBL31184 BENZO[DEF]CHRYSENE 0.5 2 -
CHEMBL1201346 BALSALAZIDE 4.0 2 -
CHEMBL1598608 AZASETRON 2.0 2 -
CHEMBL24 ATENOLOL 4.0 2 -
CHEMBL277474 ANTIPYRINE 3.0 2 -
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER — 2 -
CHEMBL894 BUPROPION 4.0 2 -
CHEMBL1077 BROMFENAC 4.0 2 -
CHEMBL1231530 BETAMIPRON 2.0 2 -
CHEMBL12089 BERBERINE CHLORIDE 1.0 2 -
CHEMBL221753 BENZETHONIUM CHLORIDE 2.0 2 -
CHEMBL701 BACLOFEN 4.0 2 -
CHEMBL1095699 AZASERINE 2.0 2 -
CHEMBL3084803 ASTROMICIN 2.0 2 -
CHEMBL211501 ANTIMYCIN A — 2 -
CHEMBL14 CARBACHOL 4.0 2 -
CHEMBL1458880 CADMIUM DICHLORIDE — 2 -
CHEMBL1200396 BUPIVACAINE HYDROCHLORIDE 4.0 2 -
CHEMBL844 BRIMONIDINE 4.0 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL742 KETAMINE Ki = 684.0 nM 6.17
CHEMBL742 KETAMINE IC50 = 1010.0 nM 6.00
CHEMBL52440 DEXTROMETHORPHAN Ki = 1636.0 nM 5.79
CHEMBL52440 DEXTROMETHORPHAN IC50 = 2415.0 nM 5.62
CHEMBL660 AMANTADINE Ki = 21666.0 nM 4.66
CHEMBL660 AMANTADINE IC50 = 31983.0 nM 4.50
CHEMBL91 MICONAZOLE IC50 - — -
CHEMBL741 LAMOTRIGINE IC50 - — -
CHEMBL91 MICONAZOLE Ki - — -
CHEMBL80 NALOXONE IC50 - — -
CHEMBL80 NALOXONE Ki - — -
CHEMBL1513 IRBESARTAN IC50 - — -
CHEMBL1513 IRBESARTAN Ki - — -
CHEMBL164290 N-NITROSODIETHYLAMINE IC50 - — -
CHEMBL1201237 LEVOBUNOLOL IC50 - — -
CHEMBL741 LAMOTRIGINE Ki - — -
CHEMBL1201139 MEGESTROL ACETATE IC50 - — -
CHEMBL878 METOLAZONE Ki - — -
CHEMBL878 METOLAZONE IC50 - — -
CHEMBL313493 METHANESULFONIC ACID METHYL ESTER Ki - — -
CHEMBL313493 METHANESULFONIC ACID METHYL ESTER IC50 - — -
CHEMBL19215 METERGOLINE Ki - — -
CHEMBL19215 METERGOLINE IC50 - — -
CHEMBL164290 N-NITROSODIETHYLAMINE Ki - — -
CHEMBL503 LOVASTATIN IC50 - — -
CHEMBL1909067 — Ki - — -
CHEMBL1909067 — IC50 - — -
CHEMBL503 LOVASTATIN Ki - — -
CHEMBL86 METOCLOPRAMIDE IC50 - — -
CHEMBL975 MESNA Ki - — -
CHEMBL686 MEFENAMIC ACID IC50 - — -
CHEMBL86304 MOCLOBEMIDE IC50 - — -
CHEMBL86304 MOCLOBEMIDE Ki - — -
CHEMBL1630579 MYRTECAINE IC50 - — -
CHEMBL1630579 MYRTECAINE Ki - — -
CHEMBL19019 NALTREXONE IC50 - — -
CHEMBL19019 NALTREXONE Ki - — -
CHEMBL1354199 METHSCOPOLAMINE BROMIDE IC50 - — -
CHEMBL1354199 METHSCOPOLAMINE BROMIDE Ki - — -
CHEMBL2106399 KITASAMYCIN Ki - — -
CHEMBL86 METOCLOPRAMIDE Ki - — -
CHEMBL6437 MIANSERIN IC50 - — -
CHEMBL6437 MIANSERIN Ki - — -
CHEMBL1618305 NALOXONAZINE IC50 - — -
CHEMBL1618305 NALOXONAZINE Ki - — -
CHEMBL92401 IPRONIAZID IC50 - — -
CHEMBL92401 IPRONIAZID Ki - — -
CHEMBL64391 ITRACONAZOLE IC50 - — -
CHEMBL64391 ITRACONAZOLE Ki - — -
CHEMBL2106399 KITASAMYCIN IC50 - — -