Assay Detail
Binding
CHEMBL1909168
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DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 5.28 | 6.91 |
| Ki | 871 | 5.30 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1221512 | — | — | 2 | 6.94 |
| CHEMBL6067481 | COLISTIN | 4.0 | 2 | 6.60 |
| CHEMBL1201469 | GRAMICIDIN | 4.0 | 2 | 5.72 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 2 | 5.67 |
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | — | 2 | 5.46 |
| CHEMBL404811 | DIGITONIN | — | 2 | 5.44 |
| CHEMBL508112 | BENZOTHIAZYL DISULFIDE | — | 2 | 5.43 |
| CHEMBL809 | SERTRALINE | 4.0 | 2 | 5.37 |
| CHEMBL11359 | CISPLATIN | 4.0 | 2 | 5.22 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 2 | 5.15 |
| CHEMBL633 | AMIODARONE | 4.0 | 2 | 5.05 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 2 | 5.05 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 2 | 4.79 |
| CHEMBL91 | MICONAZOLE | 4.0 | 2 | 4.67 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 2 | 4.60 |
| CHEMBL7002 | CIGLITAZONE | 2.0 | 2 | 4.57 |
| CHEMBL808 | ECONAZOLE | 4.0 | 2 | 4.43 |
| CHEMBL1200558 | BACITRACIN | 4.0 | 2 | - |
| CHEMBL388590 | BENZBROMARONE | 4.0 | 2 | - |
| CHEMBL844 | BRIMONIDINE | 4.0 | 2 | - |
| CHEMBL1200396 | BUPIVACAINE HYDROCHLORIDE | 4.0 | 2 | - |
| CHEMBL1458880 | CADMIUM DICHLORIDE | — | 2 | - |
| CHEMBL14 | CARBACHOL | 4.0 | 2 | - |
| CHEMBL211501 | ANTIMYCIN A | — | 2 | - |
| CHEMBL1095699 | AZASERINE | 2.0 | 2 | - |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | 2.0 | 2 | - |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 2 | - |
| CHEMBL1231530 | BETAMIPRON | 2.0 | 2 | - |
| CHEMBL3084803 | ASTROMICIN | 2.0 | 2 | - |
| CHEMBL701 | BACLOFEN | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1221512 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL1221512 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL6067481 | COLISTIN | Ki | = | 249.0 | nM | 6.60 |
| CHEMBL6067481 | COLISTIN | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL1201469 | GRAMICIDIN | Ki | = | 1888.0 | nM | 5.72 |
| CHEMBL1201469 | GRAMICIDIN | IC50 | = | 2013.0 | nM | 5.70 |
| CHEMBL296419 | ASTEMIZOLE | Ki | = | 2123.0 | nM | 5.67 |
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 2263.0 | nM | 5.64 |
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | Ki | = | 3495.0 | nM | 5.46 |
| CHEMBL404811 | DIGITONIN | Ki | = | 3639.0 | nM | 5.44 |
| CHEMBL508112 | BENZOTHIAZYL DISULFIDE | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL334255 | CETYLPYRIDINIUM BROMIDE | IC50 | = | 3726.0 | nM | 5.43 |
| CHEMBL508112 | BENZOTHIAZYL DISULFIDE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL404811 | DIGITONIN | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL809 | SERTRALINE | Ki | = | 4313.2 | nM | 5.37 |
| CHEMBL809 | SERTRALINE | IC50 | = | 4598.0 | nM | 5.34 |
| CHEMBL11359 | CISPLATIN | Ki | = | 6035.0 | nM | 5.22 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 6434.0 | nM | 5.19 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 7145.0 | nM | 5.15 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 7617.0 | nM | 5.12 |
| CHEMBL633 | AMIODARONE | Ki | = | 8909.0 | nM | 5.05 |
| CHEMBL726 | FLUPHENAZINE | Ki | = | 8929.0 | nM | 5.05 |
| CHEMBL633 | AMIODARONE | IC50 | = | 9497.0 | nM | 5.02 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 9518.0 | nM | 5.02 |
| CHEMBL428647 | PACLITAXEL | Ki | = | 16072.0 | nM | 4.79 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 17133.0 | nM | 4.77 |
| CHEMBL91 | MICONAZOLE | Ki | = | 21206.0 | nM | 4.67 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 22607.0 | nM | 4.65 |
| CHEMBL83 | TAMOXIFEN | Ki | = | 24886.0 | nM | 4.60 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 26529.0 | nM | 4.58 |
| CHEMBL7002 | CIGLITAZONE | Ki | = | 26848.0 | nM | 4.57 |
| CHEMBL7002 | CIGLITAZONE | IC50 | = | 28621.0 | nM | 4.54 |
| CHEMBL808 | ECONAZOLE | Ki | = | 37089.0 | nM | 4.43 |
| CHEMBL808 | ECONAZOLE | IC50 | = | 39538.0 | nM | 4.40 |
| CHEMBL1373 | MODAFINIL | IC50 | - | — | - | |
| CHEMBL1373 | MODAFINIL | Ki | - | — | - | |
| CHEMBL1201151 | MESTRANOL | Ki | - | — | - | |
| CHEMBL2106399 | KITASAMYCIN | IC50 | - | — | - | |
| CHEMBL64391 | ITRACONAZOLE | Ki | - | — | - | |
| CHEMBL64391 | ITRACONAZOLE | IC50 | - | — | - | |
| CHEMBL92401 | IPRONIAZID | Ki | - | — | - | |
| CHEMBL92401 | IPRONIAZID | IC50 | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | Ki | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | IC50 | - | — | - | |
| CHEMBL6437 | MIANSERIN | Ki | - | — | - | |
| CHEMBL6437 | MIANSERIN | IC50 | - | — | - | |
| CHEMBL86 | METOCLOPRAMIDE | Ki | - | — | - | |
| CHEMBL86 | METOCLOPRAMIDE | IC50 | - | — | - | |
| CHEMBL975 | MESNA | Ki | - | — | - | |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | Ki | - | — | - |