Assay Detail
Functional
CHEMBL1963706
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: RET
740
Total Activities
726
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Category | other |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase receptor Ret (CHEMBL2041) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 740 | 6.61 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1972220 | — | — | 1 | 9.20 |
| CHEMBL1964692 | — | — | 1 | 9.20 |
| CHEMBL1965170 | — | — | 1 | 9.00 |
| CHEMBL1986851 | — | — | 1 | 9.00 |
| CHEMBL1081312 | — | — | 1 | 8.90 |
| CHEMBL1967878 | CENISERTIB | 2.0 | 1 | 8.90 |
| CHEMBL1981047 | — | — | 1 | 8.80 |
| CHEMBL1989708 | — | — | 1 | 8.80 |
| CHEMBL1999414 | — | — | 1 | 8.80 |
| CHEMBL1980995 | — | — | 1 | 8.60 |
| CHEMBL2000335 | — | — | 1 | 8.60 |
| CHEMBL1990885 | — | — | 1 | 8.60 |
| CHEMBL1980297 | ILORASERTIB | 2.0 | 1 | 8.60 |
| CHEMBL1983111 | — | — | 1 | 8.50 |
| CHEMBL1979516 | — | — | 1 | 8.50 |
| CHEMBL1994938 | — | — | 1 | 8.50 |
| CHEMBL1982466 | — | — | 1 | 8.50 |
| CHEMBL2004290 | — | — | 1 | 8.50 |
| CHEMBL1997892 | — | — | 1 | 8.50 |
| CHEMBL1970142 | — | — | 1 | 8.50 |
| CHEMBL2005886 | — | — | 1 | 8.50 |
| CHEMBL1988387 | — | — | 1 | 8.40 |
| CHEMBL1977134 | — | — | 1 | 8.40 |
| CHEMBL371206 | — | — | 1 | 8.40 |
| CHEMBL1993661 | — | — | 1 | 8.40 |
| CHEMBL1980407 | — | — | 1 | 8.30 |
| CHEMBL2004716 | — | — | 1 | 8.30 |
| CHEMBL522892 | DOVITINIB | 3.0 | 1 | 8.30 |
| CHEMBL1979690 | — | — | 1 | 8.30 |
| CHEMBL574738 | AST-487 | 1.0 | 1 | 8.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1964692 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL1972220 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL1986851 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1965170 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1967878 | CENISERTIB | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL1081312 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL1989708 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL1981047 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL1999414 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL1980297 | ILORASERTIB | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL1990885 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL1980995 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL2000335 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL1979516 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL1970142 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL1983111 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL1997892 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL2004290 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL1982466 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL1994938 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL2005886 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL1993661 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL1988387 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL1977134 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL371206 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL1980407 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL522892 | DOVITINIB | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL1979690 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL2004716 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL574738 | AST-487 | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL1981725 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL272453 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL196363 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL1997617 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL1980329 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL49120 | PD-0166285 | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL2006564 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL1997924 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL1992306 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL1996646 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL508928 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL213505 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1998585 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL491473 | CEDIRANIB | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1976220 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1983923 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL2006715 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1973516 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL306380 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1969502 | — | Ki | = | 10.0 | nM | 8.00 |