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Assay Detail

CHEMBL1963749

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: LIMK1
ChEMBL ↗
775
Total Activities
768
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

LIM domain kinase 1 (CHEMBL3836) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 775 5.76 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1983715 — — 1 8.00
CHEMBL1967878 CENISERTIB 2.0 1 7.80
CHEMBL1993661 — — 1 7.70
CHEMBL1991734 — — 1 7.60
CHEMBL1969502 — — 1 7.50
CHEMBL1972355 — — 1 7.50
CHEMBL1970879 — — 1 7.50
CHEMBL1997335 — — 1 7.50
CHEMBL302449 GO-6976 — 1 7.30
CHEMBL1989267 — — 1 7.20
CHEMBL1994938 — — 1 7.20
CHEMBL2006778 — — 1 7.10
CHEMBL1974664 — — 1 7.10
CHEMBL1983575 — — 1 7.10
CHEMBL1825138 — — 1 7.00
CHEMBL1988581 — — 1 7.00
CHEMBL1981047 — — 1 7.00
CHEMBL491758 — — 1 7.00
CHEMBL1982413 — — 1 7.00
CHEMBL1980995 — — 1 7.00
CHEMBL1967116 — — 1 6.90
CHEMBL1983111 — — 1 6.90
CHEMBL1970317 — — 1 6.90
CHEMBL1991800 — — 1 6.90
CHEMBL1992371 — — 1 6.90
CHEMBL1421720 — — 1 6.80
CHEMBL508928 — — 1 6.80
CHEMBL1081312 — — 1 6.80
CHEMBL1978371 — — 1 6.80
CHEMBL1973359 — — 1 6.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1983715 — Ki = 10.0 nM 8.00
CHEMBL1967878 CENISERTIB Ki = 15.85 nM 7.80
CHEMBL1993661 — Ki = 19.95 nM 7.70
CHEMBL1991734 — Ki = 25.12 nM 7.60
CHEMBL1969502 — Ki = 31.62 nM 7.50
CHEMBL1972355 — Ki = 31.62 nM 7.50
CHEMBL1997335 — Ki = 31.62 nM 7.50
CHEMBL1970879 — Ki = 31.62 nM 7.50
CHEMBL302449 GO-6976 Ki = 50.12 nM 7.30
CHEMBL1994938 — Ki = 63.1 nM 7.20
CHEMBL1989267 — Ki = 63.1 nM 7.20
CHEMBL1983575 — Ki = 79.43 nM 7.10
CHEMBL1974664 — Ki = 79.43 nM 7.10
CHEMBL2006778 — Ki = 79.43 nM 7.10
CHEMBL1982413 — Ki = 100.0 nM 7.00
CHEMBL1980995 — Ki = 100.0 nM 7.00
CHEMBL491758 — Ki = 100.0 nM 7.00
CHEMBL1988581 — Ki = 100.0 nM 7.00
CHEMBL1825138 — Ki = 100.0 nM 7.00
CHEMBL1981047 — Ki = 100.0 nM 7.00
CHEMBL1991800 — Ki = 125.89 nM 6.90
CHEMBL1983111 — Ki = 125.89 nM 6.90
CHEMBL1970317 — Ki = 125.89 nM 6.90
CHEMBL1992371 — Ki = 125.89 nM 6.90
CHEMBL1967116 — Ki = 125.89 nM 6.90
CHEMBL1081312 — Ki = 158.49 nM 6.80
CHEMBL1975128 — Ki = 158.49 nM 6.80
CHEMBL1999484 — Ki = 158.49 nM 6.80
CHEMBL1421720 — Ki = 158.49 nM 6.80
CHEMBL1978371 — Ki = 158.49 nM 6.80
CHEMBL1973359 — Ki = 158.49 nM 6.80
CHEMBL508928 — Ki = 158.49 nM 6.80
CHEMBL1988805 — Ki = 199.53 nM 6.70
CHEMBL2004025 — Ki = 199.53 nM 6.70
CHEMBL1972584 — Ki = 199.53 nM 6.70
CHEMBL1972584 — Ki = 199.53 nM 6.70
CHEMBL2000271 — Ki = 199.53 nM 6.70
CHEMBL1983980 — Ki = 199.53 nM 6.70
CHEMBL1982476 — Ki = 199.53 nM 6.70
CHEMBL1975923 — Ki = 199.53 nM 6.70
CHEMBL1999112 — Ki = 199.53 nM 6.70
CHEMBL1987648 — Ki = 199.53 nM 6.70
CHEMBL1992042 — Ki = 199.53 nM 6.70
CHEMBL191003 JNJ-7706621 Ki = 199.53 nM 6.70
CHEMBL2005886 — Ki = 199.53 nM 6.70
CHEMBL5416410 DASATINIB Ki = 251.19 nM 6.60
CHEMBL509032 TAE-684 Ki = 251.19 nM 6.60
CHEMBL1082440 — Ki = 251.19 nM 6.60
CHEMBL1980167 — Ki = 251.19 nM 6.60
CHEMBL1993243 — Ki = 251.19 nM 6.60