Assay Detail
Functional
CHEMBL1963751
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ROS1
496
Total Activities
488
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Category | other |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase ROS (CHEMBL5568) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 496 | 6.64 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1993661 | — | — | 1 | 9.40 |
| CHEMBL1980995 | — | — | 1 | 9.30 |
| CHEMBL1997924 | — | — | 1 | 9.00 |
| CHEMBL1825138 | — | — | 1 | 8.80 |
| CHEMBL1970142 | — | — | 1 | 8.70 |
| CHEMBL461876 | — | — | 1 | 8.60 |
| CHEMBL1967878 | CENISERTIB | 2.0 | 1 | 8.60 |
| CHEMBL1988387 | — | — | 1 | 8.50 |
| CHEMBL1982466 | — | — | 1 | 8.40 |
| CHEMBL2005886 | — | — | 1 | 8.30 |
| CHEMBL458997 | — | — | 1 | 8.30 |
| CHEMBL1980297 | ILORASERTIB | 2.0 | 1 | 8.30 |
| CHEMBL1974328 | — | — | 1 | 8.20 |
| CHEMBL475251 | R-406 | 2.0 | 1 | 8.20 |
| CHEMBL1981047 | — | — | 1 | 8.10 |
| CHEMBL1993424 | — | — | 1 | 8.10 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 7.90 |
| CHEMBL2000393 | — | — | 1 | 7.70 |
| CHEMBL1970189 | — | — | 1 | 7.70 |
| CHEMBL1980391 | RG-1530 | 1.0 | 1 | 7.70 |
| CHEMBL1988163 | — | — | 1 | 7.60 |
| CHEMBL2001485 | — | — | 1 | 7.60 |
| CHEMBL1983932 | — | — | 1 | 7.60 |
| CHEMBL1988838 | — | — | 1 | 7.50 |
| CHEMBL1983111 | — | — | 1 | 7.50 |
| CHEMBL1996791 | — | — | 1 | 7.50 |
| CHEMBL1978448 | — | — | 1 | 7.30 |
| CHEMBL1987034 | — | — | 1 | 7.20 |
| CHEMBL2004311 | — | — | 1 | 7.20 |
| CHEMBL1998112 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1993661 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL1980995 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL1997924 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1825138 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL1970142 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL461876 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL1967878 | CENISERTIB | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL1988387 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL1982466 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL2005886 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL1980297 | ILORASERTIB | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL458997 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL475251 | R-406 | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL1974328 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL1981047 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL1993424 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL1084546 | PF-00562271 | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL1980391 | RG-1530 | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL2000393 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL1970189 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL2001485 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1983932 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1988163 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL1983111 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1988838 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1996791 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1978448 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL1987034 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL1982660 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL243088 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL2004311 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL1982660 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL1998112 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL1996817 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL244378 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL396523 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL1982711 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL1969502 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL1970314 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1989708 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1981725 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL482967 | CYC-116 | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL1973961 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL1972584 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL1978099 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL572878 | TOZASERTIB | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL1986943 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL483158 | ALISERTIB | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL1976134 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL1986263 | — | Ki | = | 158.49 | nM | 6.80 |