Compound Detail
CHEMBL1970189
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Basic Information
| ChEMBL ID | CHEMBL1970189 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GPWYRDPTGJYJNL-UHFFFAOYSA-N |
10
Targets
11
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
286.7
MW (Da)
2.59
ALogP
4
HBA
2
HBD
87.7
PSA (Ų)
0.84
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 10 meas. best 7.7
IC50 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase ROS CHEMBL5568 | Ki | 7.7 | 7.7 | 19.9 | 1 |
| STE20-like serine/threonine-protein kinase CHEMBL4202 | Ki | 5.7 | 5.7 | 1995.3 | 1 |
| MAP/microtubule affinity-regulating kinase 3 CHEMBL5600 | Ki | 5.5 | 5.5 | 3162.3 | 1 |
| Cyclin-dependent kinase 5 CHEMBL4036 | Ki | 5.4 | 5.4 | 3981.1 | 1 |
| Dual specificity protein kinase CLK2 CHEMBL4225 | Ki | 5.3 | 5.3 | 5011.9 | 1 |
| Glycogen synthase kinase-3 beta CHEMBL262 | Ki | 5.2 | 5.2 | 6309.6 | 1 |
| Cyclin-dependent kinase 1 CHEMBL308 | Ki | 5.2 | 5.2 | 6309.6 | 1 |
| LIM domain kinase 1 CHEMBL3836 | Ki | 5.1 | 5.1 | 7943.3 | 1 |
| Dual specificity protein kinase CLK4 CHEMBL4203 | Ki | 5.1 | 5.1 | 7943.3 | 1 |
| Mitogen-activated protein kinase kinase kinase kinase 5 CHEMBL4852 | Ki | 5.1 | 5.1 | 7943.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30015075 | 10.1016/j.ejmech.2018.07.007 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine