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Assay Detail

CHEMBL1963756

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MARK3
ChEMBL ↗
770
Total Activities
760
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

MAP/microtubule affinity-regulating kinase 3 (CHEMBL5600) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 770 6.01 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1980995 — — 1 9.40
CHEMBL2000724 — — 1 9.00
CHEMBL1725279 SP-600125 — 1 8.40
CHEMBL1993661 — — 1 8.20
CHEMBL1241473 — — 1 8.10
CHEMBL1967878 CENISERTIB 2.0 1 7.90
CHEMBL1983111 — — 1 7.80
CHEMBL509032 TAE-684 — 1 7.80
CHEMBL302449 GO-6976 — 1 7.70
CHEMBL1987034 — — 1 7.50
CHEMBL1971029 — — 1 7.50
CHEMBL1973540 — — 1 7.40
CHEMBL2001751 — — 1 7.40
CHEMBL1997129 — — 1 7.30
CHEMBL1981047 — — 1 7.30
CHEMBL1998121 — — 1 7.30
CHEMBL482967 CYC-116 1.0 1 7.30
CHEMBL1986943 — — 2 7.30
CHEMBL1966628 — — 1 7.30
CHEMBL1998159 — — 1 7.20
CHEMBL1991078 — — 1 7.20
CHEMBL592030 — — 1 7.20
CHEMBL2003420 — — 1 7.10
CHEMBL1999931 — — 1 7.10
CHEMBL2005886 — — 1 7.00
CHEMBL1990583 — — 1 7.00
CHEMBL1998585 — — 1 7.00
CHEMBL1982957 — — 1 7.00
CHEMBL522892 DOVITINIB 3.0 1 6.90
CHEMBL1976732 — — 1 6.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1980995 — Ki = 0.3981 nM 9.40
CHEMBL2000724 — Ki = 1.0 nM 9.00
CHEMBL1725279 SP-600125 Ki = 3.981 nM 8.40
CHEMBL1993661 — Ki = 6.31 nM 8.20
CHEMBL1241473 — Ki = 7.943 nM 8.10
CHEMBL1967878 CENISERTIB Ki = 12.59 nM 7.90
CHEMBL1983111 — Ki = 15.85 nM 7.80
CHEMBL509032 TAE-684 Ki = 15.85 nM 7.80
CHEMBL302449 GO-6976 Ki = 19.95 nM 7.70
CHEMBL1987034 — Ki = 31.62 nM 7.50
CHEMBL1971029 — Ki = 31.62 nM 7.50
CHEMBL2001751 — Ki = 39.81 nM 7.40
CHEMBL1973540 — Ki = 39.81 nM 7.40
CHEMBL482967 CYC-116 Ki = 50.12 nM 7.30
CHEMBL1986943 — Ki = 50.12 nM 7.30
CHEMBL1986943 — Ki = 50.12 nM 7.30
CHEMBL1966628 — Ki = 50.12 nM 7.30
CHEMBL1997129 — Ki = 50.12 nM 7.30
CHEMBL1981047 — Ki = 50.12 nM 7.30
CHEMBL1998121 — Ki = 50.12 nM 7.30
CHEMBL592030 — Ki = 63.1 nM 7.20
CHEMBL1991078 — Ki = 63.1 nM 7.20
CHEMBL1998159 — Ki = 63.1 nM 7.20
CHEMBL2003420 — Ki = 79.43 nM 7.10
CHEMBL1999931 — Ki = 79.43 nM 7.10
CHEMBL2005886 — Ki = 100.0 nM 7.00
CHEMBL1990583 — Ki = 100.0 nM 7.00
CHEMBL1982957 — Ki = 100.0 nM 7.00
CHEMBL1998585 — Ki = 100.0 nM 7.00
CHEMBL1973395 — Ki = 125.89 nM 6.90
CHEMBL590109 — Ki = 125.89 nM 6.90
CHEMBL1987054 — Ki = 125.89 nM 6.90
CHEMBL1976732 — Ki = 125.89 nM 6.90
CHEMBL522892 DOVITINIB Ki = 125.89 nM 6.90
CHEMBL2006439 — Ki = 158.49 nM 6.80
CHEMBL373598 — Ki = 158.49 nM 6.80
CHEMBL1984162 — Ki = 158.49 nM 6.80
CHEMBL1969588 — Ki = 158.49 nM 6.80
CHEMBL1995813 — Ki = 158.49 nM 6.80
CHEMBL1992073 — Ki = 158.49 nM 6.80
CHEMBL1990885 — Ki = 199.53 nM 6.70
CHEMBL2003638 — Ki = 199.53 nM 6.70
CHEMBL1992922 — Ki = 199.53 nM 6.70
CHEMBL1964399 — Ki = 199.53 nM 6.70
CHEMBL244378 — Ki = 199.53 nM 6.70
CHEMBL1996817 — Ki = 199.53 nM 6.70
CHEMBL1084546 PF-00562271 Ki = 199.53 nM 6.70
CHEMBL2000393 — Ki = 199.53 nM 6.70
CHEMBL1974328 — Ki = 251.19 nM 6.60
CHEMBL1969523 — Ki = 251.19 nM 6.60