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Assay Detail

CHEMBL1963786

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MKNK2
ChEMBL ↗
623
Total Activities
615
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

MAP kinase-interacting serine/threonine-protein kinase 2 (CHEMBL4204) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 623 6.04 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1999153 — — 1 8.00
CHEMBL1997129 — — 1 7.80
CHEMBL1972576 — — 1 7.70
CHEMBL1999279 — — 1 7.60
CHEMBL411903 — — 1 7.60
CHEMBL592030 — — 1 7.60
CHEMBL1969523 — — 1 7.60
CHEMBL1988594 — — 1 7.60
CHEMBL385478 — — 1 7.60
CHEMBL1986943 — — 2 7.40
CHEMBL1969473 — — 1 7.40
CHEMBL482767 SNS-314 1.0 1 7.30
CHEMBL2007002 — — 1 7.30
CHEMBL1965507 — — 1 7.20
CHEMBL475251 R-406 2.0 1 7.20
CHEMBL1981079 — — 1 7.20
CHEMBL1968459 — — 1 7.20
CHEMBL184847 — — 1 7.10
CHEMBL1965660 — — 2 7.10
CHEMBL213207 — — 1 7.10
CHEMBL2000335 — — 1 7.10
CHEMBL2006439 — — 1 7.10
CHEMBL1242373 — — 1 7.10
CHEMBL1987034 — — 1 7.00
CHEMBL1967116 — — 1 7.00
CHEMBL1982135 — — 1 7.00
CHEMBL1985095 — — 1 7.00
CHEMBL1982711 — — 1 7.00
CHEMBL1970203 — — 1 7.00
CHEMBL1995813 — — 1 6.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1999153 — Ki = 10.0 nM 8.00
CHEMBL1997129 — Ki = 15.85 nM 7.80
CHEMBL1972576 — Ki = 19.95 nM 7.70
CHEMBL1999279 — Ki = 25.12 nM 7.60
CHEMBL1969523 — Ki = 25.12 nM 7.60
CHEMBL411903 — Ki = 25.12 nM 7.60
CHEMBL385478 — Ki = 25.12 nM 7.60
CHEMBL592030 — Ki = 25.12 nM 7.60
CHEMBL1988594 — Ki = 25.12 nM 7.60
CHEMBL1986943 — Ki = 39.81 nM 7.40
CHEMBL1986943 — Ki = 39.81 nM 7.40
CHEMBL1969473 — Ki = 39.81 nM 7.40
CHEMBL482767 SNS-314 Ki = 50.12 nM 7.30
CHEMBL2007002 — Ki = 50.12 nM 7.30
CHEMBL1968459 — Ki = 63.1 nM 7.20
CHEMBL475251 R-406 Ki = 63.1 nM 7.20
CHEMBL1965507 — Ki = 63.1 nM 7.20
CHEMBL1981079 — Ki = 63.1 nM 7.20
CHEMBL1965660 — Ki = 79.43 nM 7.10
CHEMBL2000335 — Ki = 79.43 nM 7.10
CHEMBL213207 — Ki = 79.43 nM 7.10
CHEMBL1242373 — Ki = 79.43 nM 7.10
CHEMBL2006439 — Ki = 79.43 nM 7.10
CHEMBL1965660 — Ki = 79.43 nM 7.10
CHEMBL184847 — Ki = 79.43 nM 7.10
CHEMBL1987034 — Ki = 100.0 nM 7.00
CHEMBL1970203 — Ki = 100.0 nM 7.00
CHEMBL1982711 — Ki = 100.0 nM 7.00
CHEMBL1985095 — Ki = 100.0 nM 7.00
CHEMBL1967116 — Ki = 100.0 nM 7.00
CHEMBL1982135 — Ki = 100.0 nM 7.00
CHEMBL244378 — Ki = 125.89 nM 6.90
CHEMBL1968406 — Ki = 125.89 nM 6.90
CHEMBL2004716 — Ki = 125.89 nM 6.90
CHEMBL2000354 — Ki = 125.89 nM 6.90
CHEMBL1973540 — Ki = 125.89 nM 6.90
CHEMBL1995813 — Ki = 125.89 nM 6.90
CHEMBL1989708 — Ki = 125.89 nM 6.90
CHEMBL2003229 — Ki = 125.89 nM 6.90
CHEMBL1972142 — Ki = 158.49 nM 6.80
CHEMBL1995932 — Ki = 158.49 nM 6.80
CHEMBL1983315 — Ki = 158.49 nM 6.80
CHEMBL1994693 — Ki = 158.49 nM 6.80
CHEMBL1988387 — Ki = 158.49 nM 6.80
CHEMBL1990482 — Ki = 158.49 nM 6.80
CHEMBL371206 — Ki = 158.49 nM 6.80
CHEMBL1967878 CENISERTIB Ki = 158.49 nM 6.80
CHEMBL1969588 — Ki = 158.49 nM 6.80
CHEMBL1975128 — Ki = 158.49 nM 6.80
CHEMBL1964290 — Ki = 199.53 nM 6.70