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Assay Detail

CHEMBL1963788

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: KDR
ChEMBL ↗
1047
Total Activities
1027
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1047 6.49 9.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL273187 — — 2 9.60
CHEMBL403402 — — 1 9.50
CHEMBL1985888 — — 1 9.20
CHEMBL1980407 — — 1 9.20
CHEMBL1999414 — — 1 9.20
CHEMBL1980904 — — 1 9.10
CHEMBL1996646 — — 1 9.00
CHEMBL1986851 — — 1 9.00
CHEMBL1980297 ILORASERTIB 2.0 1 9.00
CHEMBL1973178 — — 1 9.00
CHEMBL272938 — — 1 8.90
CHEMBL1966836 — — 1 8.90
CHEMBL1972220 — — 1 8.90
CHEMBL1996649 — — 1 8.90
CHEMBL1965170 — — 1 8.90
CHEMBL1983640 — — 1 8.90
CHEMBL374044 — — 1 8.80
CHEMBL1993996 — — 1 8.80
CHEMBL271441 — — 1 8.70
CHEMBL409349 — — 1 8.70
CHEMBL253969 OSI-632 2.0 1 8.60
CHEMBL574738 AST-487 1.0 1 8.60
CHEMBL1986979 — — 1 8.50
CHEMBL1969102 — — 1 8.50
CHEMBL1993510 — — 1 8.50
CHEMBL1982465 — — 1 8.50
CHEMBL2000652 — — 2 8.50
CHEMBL404366 — — 1 8.50
CHEMBL477772 PAZOPANIB 4.0 1 8.50
CHEMBL1967116 — — 1 8.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL273187 — Ki = 0.2512 nM 9.60
CHEMBL273187 — Ki = 0.2512 nM 9.60
CHEMBL403402 — Ki = 0.3162 nM 9.50
CHEMBL1985888 — Ki = 0.631 nM 9.20
CHEMBL1980407 — Ki = 0.631 nM 9.20
CHEMBL1999414 — Ki = 0.631 nM 9.20
CHEMBL1980904 — Ki = 0.7943 nM 9.10
CHEMBL1996646 — Ki = 1.0 nM 9.00
CHEMBL1986851 — Ki = 1.0 nM 9.00
CHEMBL1973178 — Ki = 1.0 nM 9.00
CHEMBL1980297 ILORASERTIB Ki = 1.0 nM 9.00
CHEMBL1983640 — Ki = 1.259 nM 8.90
CHEMBL272938 — Ki = 1.259 nM 8.90
CHEMBL1996649 — Ki = 1.259 nM 8.90
CHEMBL1965170 — Ki = 1.259 nM 8.90
CHEMBL1966836 — Ki = 1.259 nM 8.90
CHEMBL1972220 — Ki = 1.259 nM 8.90
CHEMBL374044 — Ki = 1.585 nM 8.80
CHEMBL1993996 — Ki = 1.585 nM 8.80
CHEMBL409349 — Ki = 1.995 nM 8.70
CHEMBL271441 — Ki = 1.995 nM 8.70
CHEMBL574738 AST-487 Ki = 2.512 nM 8.60
CHEMBL253969 OSI-632 Ki = 2.512 nM 8.60
CHEMBL1967116 — Ki = 3.162 nM 8.50
CHEMBL1982465 — Ki = 3.162 nM 8.50
CHEMBL1986979 — Ki = 3.162 nM 8.50
CHEMBL1969102 — Ki = 3.162 nM 8.50
CHEMBL404366 — Ki = 3.162 nM 8.50
CHEMBL2000652 — Ki = 3.162 nM 8.50
CHEMBL2000652 — Ki = 3.162 nM 8.50
CHEMBL1993510 — Ki = 3.162 nM 8.50
CHEMBL477772 PAZOPANIB Ki = 3.162 nM 8.50
CHEMBL1974254 — Ki = 3.981 nM 8.40
CHEMBL1978166 — Ki = 3.981 nM 8.40
CHEMBL1976220 — Ki = 3.981 nM 8.40
CHEMBL1982466 — Ki = 3.981 nM 8.40
CHEMBL1978166 — Ki = 3.981 nM 8.40
CHEMBL1988437 — Ki = 3.981 nM 8.40
CHEMBL1993941 — Ki = 3.981 nM 8.40
CHEMBL1965570 — Ki = 5.012 nM 8.30
CHEMBL2002165 — Ki = 5.012 nM 8.30
CHEMBL1983963 — Ki = 5.012 nM 8.30
CHEMBL1970317 — Ki = 5.012 nM 8.30
CHEMBL1081312 — Ki = 5.012 nM 8.30
CHEMBL404367 — Ki = 5.012 nM 8.30
CHEMBL183844 — Ki = 5.012 nM 8.30
CHEMBL1964441 — Ki = 5.012 nM 8.30
CHEMBL373798 — Ki = 5.012 nM 8.30
CHEMBL1988075 — Ki = 5.012 nM 8.30
CHEMBL1967720 — Ki = 5.012 nM 8.30