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Assay Detail

CHEMBL1963791

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: EPHA2
ChEMBL ↗
705
Total Activities
692
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Ephrin type-A receptor 2 (CHEMBL2068) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 705 6.61 8.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1994938 — — 1 8.50
CHEMBL5416410 DASATINIB 4.0 1 8.40
CHEMBL1993661 — — 1 8.20
CHEMBL1982476 — — 1 8.00
CHEMBL1974664 — — 1 7.90
CHEMBL1988717 — — 1 7.90
CHEMBL1989708 — — 2 7.80
CHEMBL1964692 — — 1 7.80
CHEMBL1992306 — — 1 7.70
CHEMBL1968406 — — 1 7.70
CHEMBL1967116 — — 1 7.70
CHEMBL2004716 — — 1 7.70
CHEMBL1993243 — — 1 7.70
CHEMBL2005631 — — 1 7.70
CHEMBL1242373 — — 1 7.50
CHEMBL1981047 — — 1 7.50
CHEMBL483158 ALISERTIB 3.0 1 7.50
CHEMBL1984162 — — 1 7.50
CHEMBL213505 — — 1 7.40
CHEMBL1998585 — — 1 7.40
CHEMBL1990884 — — 1 7.30
CHEMBL1970083 — — 1 7.30
CHEMBL1980391 RG-1530 1.0 1 7.30
CHEMBL411903 — — 1 7.20
CHEMBL1969102 — — 1 7.20
CHEMBL1980297 ILORASERTIB 2.0 1 7.20
CHEMBL1993941 — — 1 7.10
CHEMBL1973211 — — 1 7.10
CHEMBL1997623 — — 1 7.10
CHEMBL508928 — — 1 7.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1994938 — Ki = 3.162 nM 8.50
CHEMBL5416410 DASATINIB Ki = 3.981 nM 8.40
CHEMBL1993661 — Ki = 6.31 nM 8.20
CHEMBL1982476 — Ki = 10.0 nM 8.00
CHEMBL1974664 — Ki = 12.59 nM 7.90
CHEMBL1988717 — Ki = 12.59 nM 7.90
CHEMBL1989708 — Ki = 15.85 nM 7.80
CHEMBL1964692 — Ki = 15.85 nM 7.80
CHEMBL1989708 — Ki = 19.95 nM 7.70
CHEMBL2005631 — Ki = 19.95 nM 7.70
CHEMBL1992306 — Ki = 19.95 nM 7.70
CHEMBL1993243 — Ki = 19.95 nM 7.70
CHEMBL2004716 — Ki = 19.95 nM 7.70
CHEMBL1967116 — Ki = 19.95 nM 7.70
CHEMBL1968406 — Ki = 19.95 nM 7.70
CHEMBL1984162 — Ki = 31.62 nM 7.50
CHEMBL1981047 — Ki = 31.62 nM 7.50
CHEMBL1242373 — Ki = 31.62 nM 7.50
CHEMBL483158 ALISERTIB Ki = 31.62 nM 7.50
CHEMBL213505 — Ki = 39.81 nM 7.40
CHEMBL1998585 — Ki = 39.81 nM 7.40
CHEMBL1990884 — Ki = 50.12 nM 7.30
CHEMBL1980391 RG-1530 Ki = 50.12 nM 7.30
CHEMBL1970083 — Ki = 50.12 nM 7.30
CHEMBL1969102 — Ki = 63.1 nM 7.20
CHEMBL411903 — Ki = 63.1 nM 7.20
CHEMBL1980297 ILORASERTIB Ki = 63.1 nM 7.20
CHEMBL1973211 — Ki = 79.43 nM 7.10
CHEMBL1997623 — Ki = 79.43 nM 7.10
CHEMBL1993941 — Ki = 79.43 nM 7.10
CHEMBL508928 — Ki = 79.43 nM 7.10
CHEMBL371206 — Ki = 79.43 nM 7.10
CHEMBL1994321 — Ki = 100.0 nM 7.00
CHEMBL1988163 — Ki = 100.0 nM 7.00
CHEMBL475251 R-406 Ki = 100.0 nM 7.00
CHEMBL260092 — Ki = 100.0 nM 7.00
CHEMBL1981725 — Ki = 100.0 nM 7.00
CHEMBL1987054 — Ki = 100.0 nM 7.00
CHEMBL196363 — Ki = 100.0 nM 7.00
CHEMBL1979883 — Ki = 100.0 nM 7.00
CHEMBL1971947 — Ki = 100.0 nM 7.00
CHEMBL1090360 — Ki = 100.0 nM 7.00
CHEMBL262433 — Ki = 100.0 nM 7.00
CHEMBL2002165 — Ki = 100.0 nM 7.00
CHEMBL1991429 — Ki = 100.0 nM 7.00
CHEMBL1988387 — Ki = 100.0 nM 7.00
CHEMBL1984711 — Ki = 125.89 nM 6.90
CHEMBL1241473 — Ki = 125.89 nM 6.90
CHEMBL306380 — Ki = 125.89 nM 6.90
CHEMBL259084 MLN-8054 Ki = 125.89 nM 6.90