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Assay Detail

CHEMBL1963797

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: DYRK4
ChEMBL ↗
548
Total Activities
538
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Dual specificity tyrosine-phosphorylation-regulated kinase 4 (CHEMBL1075115) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 548 5.89 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1965660 — — 2 8.00
CHEMBL1981079 — — 1 7.90
CHEMBL1978448 — — 1 7.40
CHEMBL1964290 — — 1 7.30
CHEMBL1998159 — — 1 6.90
CHEMBL539474 — — 1 6.90
CHEMBL1995813 — — 1 6.80
CHEMBL225519 — — 1 6.70
CHEMBL1982957 — — 1 6.60
CHEMBL1970903 — — 1 6.60
CHEMBL1973098 — — 1 6.50
CHEMBL1974870 — — 1 6.50
CHEMBL526133 — — 1 6.50
CHEMBL396523 — — 1 6.50
CHEMBL226403 — — 1 6.50
CHEMBL1988173 — — 1 6.40
CHEMBL2001751 — — 1 6.40
CHEMBL1682540 — — 1 6.40
CHEMBL244378 — — 1 6.30
CHEMBL458997 — — 1 6.30
CHEMBL2006439 — — 1 6.30
CHEMBL2006263 — — 1 6.20
CHEMBL1982711 — — 1 6.20
CHEMBL2002726 — — 1 6.20
CHEMBL1966722 — — 1 6.10
CHEMBL592030 — — 1 6.10
CHEMBL1985074 — — 1 6.10
CHEMBL1975128 — — 1 6.00
CHEMBL1682553 — — 1 6.00
CHEMBL1997349 — — 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1965660 — Ki = 10.0 nM 8.00
CHEMBL1965660 — Ki = 10.0 nM 8.00
CHEMBL1981079 — Ki = 12.59 nM 7.90
CHEMBL1978448 — Ki = 39.81 nM 7.40
CHEMBL1964290 — Ki = 50.12 nM 7.30
CHEMBL539474 — Ki = 125.89 nM 6.90
CHEMBL1998159 — Ki = 125.89 nM 6.90
CHEMBL1995813 — Ki = 158.49 nM 6.80
CHEMBL225519 — Ki = 199.53 nM 6.70
CHEMBL1982957 — Ki = 251.19 nM 6.60
CHEMBL1970903 — Ki = 251.19 nM 6.60
CHEMBL396523 — Ki = 316.23 nM 6.50
CHEMBL526133 — Ki = 316.23 nM 6.50
CHEMBL1974870 — Ki = 316.23 nM 6.50
CHEMBL226403 — Ki = 316.23 nM 6.50
CHEMBL1973098 — Ki = 316.23 nM 6.50
CHEMBL1988173 — Ki = 398.11 nM 6.40
CHEMBL2001751 — Ki = 398.11 nM 6.40
CHEMBL1682540 — Ki = 398.11 nM 6.40
CHEMBL458997 — Ki = 501.19 nM 6.30
CHEMBL244378 — Ki = 501.19 nM 6.30
CHEMBL2006439 — Ki = 501.19 nM 6.30
CHEMBL2002726 — Ki = 630.96 nM 6.20
CHEMBL1982711 — Ki = 630.96 nM 6.20
CHEMBL2006263 — Ki = 630.96 nM 6.20
CHEMBL592030 — Ki = 794.33 nM 6.10
CHEMBL1966722 — Ki = 794.33 nM 6.10
CHEMBL1985074 — Ki = 794.33 nM 6.10
CHEMBL1975128 — Ki = 1000.0 nM 6.00
CHEMBL1997349 — Ki = 1000.0 nM 6.00
CHEMBL1991063 — Ki = 1000.0 nM 6.00
CHEMBL1682553 — Ki = 1000.0 nM 6.00
CHEMBL243088 — Ki = 1000.0 nM 6.00
CHEMBL2000354 — Ki = 1258.93 nM 5.90
CHEMBL1999931 — Ki = 1258.93 nM 5.90
CHEMBL1993661 — Ki = 1258.93 nM 5.90
CHEMBL1997846 — Ki = 1258.93 nM 5.90
CHEMBL1975138 — Ki = 1584.89 nM 5.80
CHEMBL2003286 — Ki = 1584.89 nM 5.80
CHEMBL2006010 — Ki = 1584.89 nM 5.80
CHEMBL1966628 — Ki = 1584.89 nM 5.80
CHEMBL1984274 — Ki = 1584.89 nM 5.80
CHEMBL1991674 — Ki = 1584.89 nM 5.80
CHEMBL475251 R-406 Ki = 1584.89 nM 5.80
CHEMBL1965836 — Ki = 1995.26 nM 5.70
CHEMBL1976090 — Ki = 1995.26 nM 5.70
CHEMBL2003638 — Ki = 1995.26 nM 5.70
CHEMBL1987034 — Ki = 1995.26 nM 5.70
CHEMBL1985095 — Ki = 1995.26 nM 5.70
CHEMBL1970522 — Ki = 1995.26 nM 5.70