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Assay Detail

CHEMBL1963809

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: AKT1
ChEMBL ↗
751
Total Activities
739
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 751 5.81 8.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1965836 — — 1 8.50
CHEMBL1987679 — — 1 8.20
CHEMBL1967302 — — 1 8.00
CHEMBL1998121 — — 1 8.00
CHEMBL1966524 — — 1 7.90
CHEMBL1974935 — — 1 7.70
CHEMBL1978448 — — 1 7.50
CHEMBL2000271 — — 1 7.40
CHEMBL2002726 — — 1 7.40
CHEMBL1968245 — — 1 7.20
CHEMBL1990254 — — 2 7.10
CHEMBL1983945 — — 1 7.00
CHEMBL1987756 — — 1 6.90
CHEMBL1972840 — — 1 6.90
CHEMBL539474 — — 1 6.90
CHEMBL2000685 — — 1 6.80
CHEMBL1991725 — — 1 6.80
CHEMBL1991180 — — 1 6.80
CHEMBL1988173 — — 1 6.80
CHEMBL1969502 — — 1 6.80
CHEMBL1976240 — — 1 6.70
CHEMBL592030 — — 1 6.60
CHEMBL1987034 — — 1 6.50
CHEMBL1993166 — — 1 6.40
CHEMBL1991728 — — 1 6.40
CHEMBL1982122 — — 1 6.40
CHEMBL1975138 — — 1 6.30
CHEMBL220241 GSK-269962A — 1 6.30
CHEMBL565612 SOTRASTAURIN 2.0 1 6.30
CHEMBL1995813 — — 1 6.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1965836 — Ki = 3.162 nM 8.50
CHEMBL1987679 — Ki = 6.31 nM 8.20
CHEMBL1967302 — Ki = 10.0 nM 8.00
CHEMBL1998121 — Ki = 10.0 nM 8.00
CHEMBL1966524 — Ki = 12.59 nM 7.90
CHEMBL1974935 — Ki = 19.95 nM 7.70
CHEMBL1978448 — Ki = 31.62 nM 7.50
CHEMBL2002726 — Ki = 39.81 nM 7.40
CHEMBL2000271 — Ki = 39.81 nM 7.40
CHEMBL1968245 — Ki = 63.1 nM 7.20
CHEMBL1990254 — Ki = 79.43 nM 7.10
CHEMBL1990254 — Ki = 100.0 nM 7.00
CHEMBL1983945 — Ki = 100.0 nM 7.00
CHEMBL1972840 — Ki = 125.89 nM 6.90
CHEMBL1987756 — Ki = 125.89 nM 6.90
CHEMBL539474 — Ki = 125.89 nM 6.90
CHEMBL1991180 — Ki = 158.49 nM 6.80
CHEMBL1969502 — Ki = 158.49 nM 6.80
CHEMBL2000685 — Ki = 158.49 nM 6.80
CHEMBL1991725 — Ki = 158.49 nM 6.80
CHEMBL1988173 — Ki = 158.49 nM 6.80
CHEMBL1976240 — Ki = 199.53 nM 6.70
CHEMBL592030 — Ki = 251.19 nM 6.60
CHEMBL1987034 — Ki = 316.23 nM 6.50
CHEMBL1993166 — Ki = 398.11 nM 6.40
CHEMBL1982122 — Ki = 398.11 nM 6.40
CHEMBL1991728 — Ki = 398.11 nM 6.40
CHEMBL565612 SOTRASTAURIN Ki = 501.19 nM 6.30
CHEMBL1975138 — Ki = 501.19 nM 6.30
CHEMBL220241 GSK-269962A Ki = 501.19 nM 6.30
CHEMBL1975128 — Ki = 630.96 nM 6.20
CHEMBL1970217 — Ki = 630.96 nM 6.20
CHEMBL1996543 — Ki = 630.96 nM 6.20
CHEMBL1995813 — Ki = 630.96 nM 6.20
CHEMBL1979357 — Ki = 630.96 nM 6.20
CHEMBL413779 — Ki = 630.96 nM 6.20
CHEMBL1975128 — Ki = 630.96 nM 6.20
CHEMBL1975900 — Ki = 794.33 nM 6.10
CHEMBL1682345 — Ki = 794.33 nM 6.10
CHEMBL590109 — Ki = 794.33 nM 6.10
CHEMBL2006933 — Ki = 794.33 nM 6.10
CHEMBL373598 — Ki = 1000.0 nM 6.00
CHEMBL1996831 — Ki = 1000.0 nM 6.00
CHEMBL2002346 — Ki = 1000.0 nM 6.00
CHEMBL1991846 — Ki = 1000.0 nM 6.00
CHEMBL1972158 — Ki = 1258.93 nM 5.90
CHEMBL1979718 — Ki = 1258.93 nM 5.90
CHEMBL1993781 — Ki = 1258.93 nM 5.90
CHEMBL2002992 — Ki = 1258.93 nM 5.90
CHEMBL1682552 — Ki = 1258.93 nM 5.90