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Assay Detail

CHEMBL1964115

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: LTK
ChEMBL ↗
348
Total Activities
339
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Leukocyte tyrosine kinase receptor (CHEMBL5627) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 348 6.10 8.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1983268 ENTRECTINIB 4.0 1 8.80
CHEMBL461876 — — 1 8.80
CHEMBL1164265 — — 1 8.70
CHEMBL1825138 — — 2 8.60
CHEMBL1980995 — — 1 8.50
CHEMBL1993661 — — 1 8.50
CHEMBL1980329 — — 1 8.40
CHEMBL458997 — — 1 8.10
CHEMBL1974328 — — 1 8.00
CHEMBL1164180 — — 1 8.00
CHEMBL1977138 — — 1 7.90
CHEMBL1973961 — — 1 7.90
CHEMBL1967878 CENISERTIB 2.0 1 7.80
CHEMBL1979690 — — 1 7.80
CHEMBL1988581 — — 1 7.70
CHEMBL1989708 — — 1 7.70
CHEMBL21156 — — 1 7.60
CHEMBL1967998 — — 1 7.60
CHEMBL1997335 — — 1 7.60
CHEMBL2002099 — — 2 7.50
CHEMBL2004290 — — 1 7.50
CHEMBL1981047 — — 1 7.50
CHEMBL2007421 — — 1 7.50
CHEMBL1983111 — — 1 7.40
CHEMBL1980297 ILORASERTIB 2.0 1 7.40
CHEMBL1983715 — — 1 7.30
CHEMBL1986851 — — 1 7.30
CHEMBL2005449 — — 1 7.30
CHEMBL1977749 — — 1 7.30
CHEMBL1983640 — — 1 7.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1983268 ENTRECTINIB Ki = 1.585 nM 8.80
CHEMBL461876 — Ki = 1.585 nM 8.80
CHEMBL1164265 — Ki = 1.995 nM 8.70
CHEMBL1825138 — Ki = 2.512 nM 8.60
CHEMBL1980995 — Ki = 3.162 nM 8.50
CHEMBL1993661 — Ki = 3.162 nM 8.50
CHEMBL1980329 — Ki = 3.981 nM 8.40
CHEMBL458997 — Ki = 7.943 nM 8.10
CHEMBL1974328 — Ki = 10.0 nM 8.00
CHEMBL1164180 — Ki = 10.0 nM 8.00
CHEMBL1973961 — Ki = 12.59 nM 7.90
CHEMBL1977138 — Ki = 12.59 nM 7.90
CHEMBL1979690 — Ki = 15.85 nM 7.80
CHEMBL1967878 CENISERTIB Ki = 15.85 nM 7.80
CHEMBL1989708 — Ki = 19.95 nM 7.70
CHEMBL1988581 — Ki = 19.95 nM 7.70
CHEMBL1997335 — Ki = 25.12 nM 7.60
CHEMBL1967998 — Ki = 25.12 nM 7.60
CHEMBL21156 — Ki = 25.12 nM 7.60
CHEMBL2002099 — Ki = 31.62 nM 7.50
CHEMBL2007421 — Ki = 31.62 nM 7.50
CHEMBL2004290 — Ki = 31.62 nM 7.50
CHEMBL1981047 — Ki = 31.62 nM 7.50
CHEMBL1980297 ILORASERTIB Ki = 39.81 nM 7.40
CHEMBL1983111 — Ki = 39.81 nM 7.40
CHEMBL1983715 — Ki = 50.12 nM 7.30
CHEMBL2005449 — Ki = 50.12 nM 7.30
CHEMBL1825138 — Ki = 50.12 nM 7.30
CHEMBL1986851 — Ki = 50.12 nM 7.30
CHEMBL1977749 — Ki = 50.12 nM 7.30
CHEMBL1983640 — Ki = 63.1 nM 7.20
CHEMBL2004716 — Ki = 63.1 nM 7.20
CHEMBL2006765 — Ki = 63.1 nM 7.20
CHEMBL101311 — Ki = 79.43 nM 7.10
CHEMBL1988141 — Ki = 79.43 nM 7.10
CHEMBL1973359 — Ki = 79.43 nM 7.10
CHEMBL1965170 — Ki = 79.43 nM 7.10
CHEMBL2006564 — Ki = 79.43 nM 7.10
CHEMBL1972220 — Ki = 79.43 nM 7.10
CHEMBL1999484 — Ki = 100.0 nM 7.00
CHEMBL1993877 — Ki = 100.0 nM 7.00
CHEMBL2002099 — Ki = 100.0 nM 7.00
CHEMBL1991734 — Ki = 125.89 nM 6.90
CHEMBL1973720 — Ki = 125.89 nM 6.90
CHEMBL1980407 — Ki = 125.89 nM 6.90
CHEMBL1973720 — Ki = 125.89 nM 6.90
CHEMBL1081312 — Ki = 158.49 nM 6.80
CHEMBL1972355 — Ki = 158.49 nM 6.80
CHEMBL1988692 — Ki = 199.53 nM 6.70
CHEMBL253969 OSI-632 Ki = 199.53 nM 6.70