Assay Detail
Binding
CHEMBL2432435
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Inhibition of muscarinic M4 receptor (unknown origin) by PDSP assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M4 (CHEMBL1821) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-substituted 8-aminopentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecanes as σ receptor ligands with potential neuroprotective effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 5.67 | 6.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2432039 | — | — | 1 | 6.45 |
| CHEMBL2432054 | — | — | 1 | 6.21 |
| CHEMBL2432038 | — | — | 1 | 6.15 |
| CHEMBL1643900 | — | — | 1 | 6.15 |
| CHEMBL2432048 | — | — | 1 | 6.05 |
| CHEMBL2205827 | — | — | 1 | 5.91 |
| CHEMBL2432040 | — | — | 1 | 5.90 |
| CHEMBL2432049 | — | — | 1 | 5.88 |
| CHEMBL2205829 | — | — | 1 | 5.88 |
| CHEMBL1189234 | — | — | 1 | 5.85 |
| CHEMBL2432052 | — | — | 1 | 5.55 |
| CHEMBL2205816 | — | — | 1 | 5.53 |
| CHEMBL2432044 | — | — | 1 | 5.45 |
| CHEMBL2432059 | — | — | 1 | 5.42 |
| CHEMBL2432060 | — | — | 1 | 5.41 |
| CHEMBL2432041 | — | — | 1 | 5.39 |
| CHEMBL2432061 | — | — | 1 | 5.23 |
| CHEMBL2429890 | — | — | 1 | 5.18 |
| CHEMBL2432056 | — | — | 1 | 5.17 |
| CHEMBL2432043 | — | — | 1 | 5.16 |
| CHEMBL2432042 | — | — | 1 | 5.13 |
| CHEMBL2205830 | — | — | 1 | - |
| CHEMBL2432047 | — | — | 1 | - |
| CHEMBL2205831 | — | — | 1 | - |
| CHEMBL2205835 | — | — | 1 | - |
| CHEMBL602850 | — | — | 1 | - |
| CHEMBL2432050 | — | — | 1 | - |
| CHEMBL608560 | — | — | 1 | - |
| CHEMBL2205820 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2432039 | — | Ki | = | 354.0 | nM | 6.45 |
| CHEMBL2432054 | — | Ki | = | 619.0 | nM | 6.21 |
| CHEMBL2432038 | — | Ki | = | 707.0 | nM | 6.15 |
| CHEMBL1643900 | — | Ki | = | 705.0 | nM | 6.15 |
| CHEMBL2432048 | — | Ki | = | 892.0 | nM | 6.05 |
| CHEMBL2205827 | — | Ki | = | 1233.0 | nM | 5.91 |
| CHEMBL2432040 | — | Ki | = | 1265.0 | nM | 5.90 |
| CHEMBL2432049 | — | Ki | = | 1302.0 | nM | 5.88 |
| CHEMBL2205829 | — | Ki | = | 1302.0 | nM | 5.88 |
| CHEMBL1189234 | — | Ki | = | 1415.0 | nM | 5.85 |
| CHEMBL2432052 | — | Ki | = | 2796.0 | nM | 5.55 |
| CHEMBL2205816 | — | Ki | = | 2961.0 | nM | 5.53 |
| CHEMBL2432044 | — | Ki | = | 3586.0 | nM | 5.45 |
| CHEMBL2432059 | — | Ki | = | 3809.0 | nM | 5.42 |
| CHEMBL2432060 | — | Ki | = | 3904.0 | nM | 5.41 |
| CHEMBL2432041 | — | Ki | = | 4038.0 | nM | 5.39 |
| CHEMBL2432061 | — | Ki | = | 5908.0 | nM | 5.23 |
| CHEMBL2429890 | — | Ki | = | 6528.0 | nM | 5.18 |
| CHEMBL2432056 | — | Ki | = | 6806.0 | nM | 5.17 |
| CHEMBL2432043 | — | Ki | = | 6993.0 | nM | 5.16 |
| CHEMBL2432042 | — | Ki | = | 7385.0 | nM | 5.13 |
| CHEMBL2205830 | — | Ki | - | — | - | |
| CHEMBL2432047 | — | Ki | - | — | - | |
| CHEMBL2205831 | — | Ki | - | — | - | |
| CHEMBL2205835 | — | Ki | - | — | - | |
| CHEMBL602850 | — | Ki | - | — | - | |
| CHEMBL2432050 | — | Ki | - | — | - | |
| CHEMBL608560 | — | Ki | - | — | - | |
| CHEMBL2205820 | — | Ki | - | — | - |