Compound Detail
CHEMBL2432041
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Basic Information
| ChEMBL ID | CHEMBL2432041 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MSTPNDDVMWUDFF-CAUKCHDASA-N |
7
Targets
7
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
297.4
MW (Da)
2.58
ALogP
2
HBA
0
HBD
20.3
PSA (Ų)
0.85
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 7 meas. best 6.78
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Ki | 6.78 | 6.78 | 168.0 | 1 |
| Sigma non-opioid intracellular receptor 1 CHEMBL3602 | Ki | 6.52 | 6.52 | 303.0 | 1 |
| Muscarinic acetylcholine receptor M2 CHEMBL211 | Ki | 5.76 | 5.76 | 1732.0 | 1 |
| Muscarinic acetylcholine receptor M3 CHEMBL245 | Ki | 5.75 | 5.75 | 1782.0 | 1 |
| Muscarinic acetylcholine receptor M4 CHEMBL1821 | Ki | 5.39 | 5.39 | 4038.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL238 | Ki | 5.34 | 5.34 | 4523.0 | 1 |
| Alpha-2C adrenergic receptor CHEMBL1916 | Ki | 5.3 | 5.3 | 5048.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Ki | = | 168.0 | nM | 6.78 | Displacement of [3H]-DTG from sigma-2 receptor in rat PC12 cells | 23981939 |
| Sigma non-opioid intracellular receptor 1 | Ki | = | 303.0 | nM | 6.52 | Displacement of [3H](+)-pentazocine from sigma-1 receptor in rat brain homogenat... | 23981939 |
| Muscarinic acetylcholine receptor M2 | Ki | = | 1732.0 | nM | 5.76 | Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assay | 23981939 |
| Muscarinic acetylcholine receptor M3 | Ki | = | 1782.0 | nM | 5.75 | Inhibition of muscarinic M3 receptor (unknown origin) by PDSP assay | 23981939 |
| Muscarinic acetylcholine receptor M4 | Ki | = | 4038.0 | nM | 5.39 | Inhibition of muscarinic M4 receptor (unknown origin) by PDSP assay | 23981939 |
| Sodium-dependent dopamine transporter | Ki | = | 4523.0 | nM | 5.34 | Displacement of [3H]-WIN-35,428 from human DAT expressed in HEK cell membranes | 23981939 |
| Alpha-2C adrenergic receptor | Ki | = | 5048.0 | nM | 5.3 | Inhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assay | 23981939 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23981939 | 10.1016/j.bmc.2013.07.045 | Unchecked | 4 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | 5-hydroxytryptamine receptor 1B | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | Muscarinic acetylcholine receptor M5 | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | D(2) dopamine receptor | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | D(3) dopamine receptor | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | D(4) dopamine receptor | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | GABA-A receptor; agonist GABA site | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | Histamine H1 receptor | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | Histamine H2 receptor | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | Histamine H3 receptor | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | Histamine H4 receptor | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | Muscarinic acetylcholine receptor M1 | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | 5-hydroxytryptamine receptor 1D | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | 5-hydroxytryptamine receptor 1E | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | 5-hydroxytryptamine receptor 2A | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | 5-hydroxytryptamine receptor 2B | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | 5-hydroxytryptamine receptor 2C | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | 5-hydroxytryptamine receptor 3A | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | 5-hydroxytryptamine receptor 5A | 1 |
| 23981939 | 10.1016/j.bmc.2013.07.045 | 5-hydroxytryptamine receptor 6 | 1 |
Data from ChEMBL 36 via Core Engine