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Assay Detail

CHEMBL2432437

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of muscarinic M3 receptor (unknown origin) by PDSP assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Muscarinic acetylcholine receptor M3 (CHEMBL245)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N-substituted 8-aminopentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecanes as σ receptor ligands with potential neuroprotective effects.
Banister SD, Manoli M, Barron ML, Werry EL, Kassiou M.
Bioorg Med Chem (2013) 21 : 6038 -6052
PubMed 23981939 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 5.99 6.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2205816 1 6.68
CHEMBL1189234 1 6.47
CHEMBL2432039 1 6.33
CHEMBL2432040 1 5.98
CHEMBL2432054 1 5.89
CHEMBL1643900 1 5.86
CHEMBL2205829 1 5.79
CHEMBL2205827 1 5.76
CHEMBL2432041 1 5.75
CHEMBL2432049 1 5.67
CHEMBL2432048 1 5.67
CHEMBL2205820 1 -
CHEMBL608560 1 -
CHEMBL2205835 1 -
CHEMBL602850 1 -
CHEMBL2205830 1 -
CHEMBL2205831 1 -
CHEMBL2432047 1 -
CHEMBL2432050 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2205816 Ki = 209.0 nM 6.68
CHEMBL1189234 Ki = 336.0 nM 6.47
CHEMBL2432039 Ki = 466.0 nM 6.33
CHEMBL2432040 Ki = 1058.0 nM 5.98
CHEMBL2432054 Ki = 1301.0 nM 5.89
CHEMBL1643900 Ki = 1395.0 nM 5.86
CHEMBL2205829 Ki = 1609.0 nM 5.79
CHEMBL2205827 Ki = 1728.0 nM 5.76
CHEMBL2432041 Ki = 1782.0 nM 5.75
CHEMBL2432049 Ki = 2119.0 nM 5.67
CHEMBL2432048 Ki = 2155.0 nM 5.67
CHEMBL2205820 Ki - -
CHEMBL608560 Ki - -
CHEMBL2205835 Ki - -
CHEMBL602850 Ki - -
CHEMBL2205830 Ki - -
CHEMBL2205831 Ki - -
CHEMBL2432047 Ki - -
CHEMBL2432050 Ki - -