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Assay Detail

CHEMBL3365096

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mouse TDO expressed in mouse P815B cells using L-tryptophan substrate incubated for 24 hrs by HPLC based cellular assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Cell Type P815B
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tryptophan 2,3-dioxygenase (CHEMBL1075307)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.
Röhrig UF, Majjigapu SR, Chambon M, Bron S, Pilotte L, Colau D, Van den Eynde BJ, Turcatti G, Vogel P, Zoete V, Michielin O.
Eur J Med Chem (2014) 84 : 284 -301
PubMed 25036789 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.38 5.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3318333 1 5.38
CHEMBL3318327 1 -
CHEMBL91 MICONAZOLE 4.0 1 -
CHEMBL808 ECONAZOLE 4.0 1 -
CHEMBL1201196 SERTACONAZOLE 4.0 1 -
CHEMBL1089 PHENELZINE 4.0 1 -
CHEMBL277535 BIFONAZOLE 3.0 1 -
CHEMBL356918 ENILCONAZOLE 2.0 1 -
CHEMBL1571863 ISOCONAZOLE 2.0 1 -
CHEMBL1262 OXICONAZOLE 4.0 1 -
CHEMBL1221 SULCONAZOLE 4.0 1 -
CHEMBL1562612 1 -
CHEMBL3318328 1 -
CHEMBL3318329 1 -
CHEMBL3318330 1 -
CHEMBL489102 1 -
CHEMBL3318331 1 -
CHEMBL3318332 1 -
CHEMBL157101 KETOCONAZOLE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3318333 IC50 = 4200.0 nM 5.38
CHEMBL3318327 IC50 - -
CHEMBL91 MICONAZOLE IC50 - -
CHEMBL808 ECONAZOLE IC50 - -
CHEMBL1201196 SERTACONAZOLE IC50 - -
CHEMBL1089 PHENELZINE IC50 - -
CHEMBL277535 BIFONAZOLE IC50 - -
CHEMBL356918 ENILCONAZOLE IC50 - -
CHEMBL1571863 ISOCONAZOLE IC50 - -
CHEMBL1262 OXICONAZOLE IC50 - -
CHEMBL1221 SULCONAZOLE IC50 - -
CHEMBL1562612 IC50 - -
CHEMBL3318328 IC50 - -
CHEMBL3318329 IC50 - -
CHEMBL3318330 IC50 - -
CHEMBL489102 IC50 - -
CHEMBL3318331 IC50 - -
CHEMBL3318332 IC50 - -
CHEMBL157101 KETOCONAZOLE IC50 - -