Assay Detail
Binding
CHEMBL3607735
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Binding affinity to 5'-FAM-pre-miR-372 (unknown origin) after 4 hrs by fluorescence assay in presence of 100-fold excess of Escherichia coli tRNA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 5.20 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL529 | AZITHROMYCIN | 4.0 | 1 | 5.72 |
| CHEMBL1200699 | DOXYCYCLINE | 4.0 | 1 | 5.70 |
| CHEMBL1434 | MINOCYCLINE | 4.0 | 1 | 5.70 |
| CHEMBL6067485 | GENTAMICIN | 4.0 | 1 | 5.38 |
| CHEMBL1517 | OXYTETRACYCLINE | 4.0 | 1 | 5.10 |
| CHEMBL532 | ERYTHROMYCIN | 4.0 | 1 | 5.06 |
| CHEMBL1909452 | APRAMYCIN | 2.0 | 1 | 5.04 |
| CHEMBL184618 | FRAMYCETIN | 3.0 | 1 | 4.93 |
| CHEMBL372795 | STREPTOMYCIN | 4.0 | 1 | 4.21 |
| CHEMBL370143 | PAROMOMYCIN | 4.0 | 1 | - |
| CHEMBL427409 | NEAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL529 | AZITHROMYCIN | Kd | = | 1900.0 | nM | 5.72 |
| CHEMBL1200699 | DOXYCYCLINE | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL1434 | MINOCYCLINE | Kd | = | 1980.0 | nM | 5.70 |
| CHEMBL6067485 | GENTAMICIN | Kd | = | 4200.0 | nM | 5.38 |
| CHEMBL1517 | OXYTETRACYCLINE | Kd | = | 8010.0 | nM | 5.10 |
| CHEMBL532 | ERYTHROMYCIN | Kd | = | 8730.0 | nM | 5.06 |
| CHEMBL1909452 | APRAMYCIN | Kd | = | 9050.0 | nM | 5.04 |
| CHEMBL184618 | FRAMYCETIN | Kd | = | 11700.0 | nM | 4.93 |
| CHEMBL372795 | STREPTOMYCIN | Kd | = | 61100.0 | nM | 4.21 |
| CHEMBL370143 | PAROMOMYCIN | Kd | = | 133200.0 | nM | - |
| CHEMBL427409 | NEAMINE | Kd | = | 394000.0 | nM | - |