Assay Detail
Binding
CHEMBL3607737
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Binding affinity to 5'-FAM-pre-miR-372 (unknown origin) after 4 hrs by fluorescence assay in presence of 100-fold excess of 15-mer DNA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 5.09 | 5.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1434 | MINOCYCLINE | 4.0 | 1 | 5.84 |
| CHEMBL1200699 | DOXYCYCLINE | 4.0 | 1 | 5.79 |
| CHEMBL1909452 | APRAMYCIN | 2.0 | 1 | 5.18 |
| CHEMBL529 | AZITHROMYCIN | 4.0 | 1 | 5.13 |
| CHEMBL6067485 | GENTAMICIN | 4.0 | 1 | 5.09 |
| CHEMBL1517 | OXYTETRACYCLINE | 4.0 | 1 | 4.99 |
| CHEMBL184618 | FRAMYCETIN | 3.0 | 1 | 4.95 |
| CHEMBL532 | ERYTHROMYCIN | 4.0 | 1 | 4.51 |
| CHEMBL372795 | STREPTOMYCIN | 4.0 | 1 | 4.32 |
| CHEMBL370143 | PAROMOMYCIN | 4.0 | 1 | - |
| CHEMBL427409 | NEAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1434 | MINOCYCLINE | Kd | = | 1450.0 | nM | 5.84 |
| CHEMBL1200699 | DOXYCYCLINE | Kd | = | 1620.0 | nM | 5.79 |
| CHEMBL1909452 | APRAMYCIN | Kd | = | 6550.0 | nM | 5.18 |
| CHEMBL529 | AZITHROMYCIN | Kd | = | 7430.0 | nM | 5.13 |
| CHEMBL6067485 | GENTAMICIN | Kd | = | 8100.0 | nM | 5.09 |
| CHEMBL1517 | OXYTETRACYCLINE | Kd | = | 10200.0 | nM | 4.99 |
| CHEMBL184618 | FRAMYCETIN | Kd | = | 11300.0 | nM | 4.95 |
| CHEMBL532 | ERYTHROMYCIN | Kd | = | 30700.0 | nM | 4.51 |
| CHEMBL372795 | STREPTOMYCIN | Kd | = | 48200.0 | nM | 4.32 |
| CHEMBL370143 | PAROMOMYCIN | Kd | = | 167000.0 | nM | - |
| CHEMBL427409 | NEAMINE | Kd | = | 248000.0 | nM | - |