Assay Detail
ADMET
CHEMBL4040133
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Inhibition of CYP2C9 (unknown origin)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.40 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2325016 | — | — | 1 | 7.44 |
| CHEMBL2324405 | — | — | 1 | 7.43 |
| CHEMBL2325350 | — | — | 1 | 7.41 |
| CHEMBL2325330 | — | — | 1 | 7.08 |
| CHEMBL2324755 | — | — | 1 | 7.00 |
| CHEMBL2323074 | — | — | 1 | 6.75 |
| CHEMBL2324391 | — | — | 1 | 6.74 |
| CHEMBL2324742 | — | — | 1 | 6.69 |
| CHEMBL2325622 | — | — | 1 | 6.58 |
| CHEMBL2325013 | — | — | 1 | 6.55 |
| CHEMBL2325014 | PF-05089771 | 2.0 | 1 | 6.52 |
| CHEMBL2323073 | — | — | 1 | 6.49 |
| CHEMBL2325619 | — | — | 1 | 6.43 |
| CHEMBL2324753 | — | — | 1 | 6.29 |
| CHEMBL2325601 | — | — | 1 | 6.26 |
| CHEMBL2325627 | — | — | 1 | 6.18 |
| CHEMBL2325038 | — | — | 1 | 6.05 |
| CHEMBL2325317 | — | — | 1 | 6.00 |
| CHEMBL2324776 | PF-05186462 | 1.0 | 1 | 5.96 |
| CHEMBL2324396 | — | — | 1 | 5.87 |
| CHEMBL2322421 | — | — | 1 | 5.86 |
| CHEMBL2325021 | — | — | 1 | 5.66 |
| CHEMBL2325020 | — | — | 1 | 5.49 |
| CHEMBL2324748 | PF-05150122 | 1.0 | 1 | 4.75 |
| CHEMBL2324388 | — | — | 1 | - |
| CHEMBL2323100 | — | — | 1 | - |
| CHEMBL2324411 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2325016 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2324405 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2325350 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2325330 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL2324755 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2323074 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2324391 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL2324742 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL2325622 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL2325013 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL2325014 | PF-05089771 | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL2323073 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL2325619 | — | IC50 | = | 372.0 | nM | 6.43 |
| CHEMBL2324753 | — | IC50 | = | 517.0 | nM | 6.29 |
| CHEMBL2325601 | — | IC50 | = | 552.0 | nM | 6.26 |
| CHEMBL2325627 | — | IC50 | = | 658.0 | nM | 6.18 |
| CHEMBL2325038 | — | IC50 | = | 894.0 | nM | 6.05 |
| CHEMBL2325317 | — | IC50 | = | 1012.0 | nM | 6.00 |
| CHEMBL2324776 | PF-05186462 | IC50 | = | 1101.0 | nM | 5.96 |
| CHEMBL2324396 | — | IC50 | = | 1365.0 | nM | 5.87 |
| CHEMBL2322421 | — | IC50 | = | 1368.0 | nM | 5.86 |
| CHEMBL2325021 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2325020 | — | IC50 | = | 3234.0 | nM | 5.49 |
| CHEMBL2324748 | PF-05150122 | IC50 | = | 17992.0 | nM | 4.75 |
| CHEMBL2324388 | — | IC50 | - | — | - | |
| CHEMBL2323100 | — | IC50 | - | — | - | |
| CHEMBL2324411 | — | IC50 | - | — | - |