Assay Detail
Functional
CHEMBL4145965
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Antitrypanosomal activity against Trypanosoma cruzi Colombiana Tc1 epimastigotes measured after 72 hrs
83
Total Activities
43
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Investigating the structure-activity relationships of N'-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against Trypanosoma cruzi to design novel active compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.08 | 5.98 |
| log1/IC50 | 40 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4172913 | — | — | 2 | 5.98 |
| CHEMBL4165020 | — | — | 2 | 5.96 |
| CHEMBL4161166 | — | — | 2 | 5.83 |
| CHEMBL4170340 | — | — | 2 | 5.75 |
| CHEMBL2413121 | — | — | 2 | 5.61 |
| CHEMBL3260878 | — | — | 2 | 5.54 |
| CHEMBL3415957 | — | — | 2 | 5.51 |
| CHEMBL3415956 | — | — | 2 | 5.41 |
| CHEMBL3260877 | — | — | 2 | 5.28 |
| CHEMBL3415958 | — | — | 2 | 5.24 |
| CHEMBL3415955 | — | — | 2 | 5.22 |
| CHEMBL3260871 | — | — | 2 | 5.21 |
| CHEMBL3260874 | — | — | 2 | 5.18 |
| CHEMBL4171032 | — | — | 2 | 5.15 |
| CHEMBL3260876 | — | — | 2 | 5.14 |
| CHEMBL3415953 | — | — | 2 | 5.13 |
| CHEMBL1733454 | — | — | 2 | 5.12 |
| CHEMBL4163560 | — | — | 2 | 5.12 |
| CHEMBL479593 | — | — | 2 | 5.09 |
| CHEMBL4167006 | — | — | 2 | 5.09 |
| CHEMBL442989 | — | — | 2 | 5.07 |
| CHEMBL479592 | — | — | 2 | 5.06 |
| CHEMBL1565322 | NIHYDRAZONE | 2.0 | 2 | 5.02 |
| CHEMBL3196547 | — | — | 2 | 5.01 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 2 | 5.00 |
| CHEMBL3415954 | — | — | 2 | 5.00 |
| CHEMBL480770 | — | — | 2 | 5.00 |
| CHEMBL1706384 | — | — | 2 | 4.99 |
| CHEMBL472882 | — | — | 2 | 4.95 |
| CHEMBL3260873 | — | — | 2 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4172913 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4165020 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL4161166 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL4170340 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL2413121 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL3260878 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL3415957 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL3415956 | — | IC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL3260877 | — | IC50 | = | 5260.0 | nM | 5.28 |
| CHEMBL3415958 | — | IC50 | = | 5790.0 | nM | 5.24 |
| CHEMBL3415955 | — | IC50 | = | 6080.0 | nM | 5.22 |
| CHEMBL3260871 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3260874 | — | IC50 | = | 6550.0 | nM | 5.18 |
| CHEMBL4171032 | — | IC50 | = | 7070.0 | nM | 5.15 |
| CHEMBL3260876 | — | IC50 | = | 7250.0 | nM | 5.14 |
| CHEMBL3415953 | — | IC50 | = | 7410.0 | nM | 5.13 |
| CHEMBL4163560 | — | IC50 | = | 7580.0 | nM | 5.12 |
| CHEMBL1733454 | — | IC50 | = | 7580.0 | nM | 5.12 |
| CHEMBL479593 | — | IC50 | = | 8080.0 | nM | 5.09 |
| CHEMBL4167006 | — | IC50 | = | 8070.0 | nM | 5.09 |
| CHEMBL442989 | — | IC50 | = | 8530.0 | nM | 5.07 |
| CHEMBL479592 | — | IC50 | = | 8640.0 | nM | 5.06 |
| CHEMBL1565322 | NIHYDRAZONE | IC50 | = | 9520.0 | nM | 5.02 |
| CHEMBL3196547 | — | IC50 | = | 9670.0 | nM | 5.01 |
| CHEMBL480770 | — | IC50 | = | 9980.0 | nM | 5.00 |
| CHEMBL3415954 | — | IC50 | = | 10060.0 | nM | 5.00 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 9930.0 | nM | 5.00 |
| CHEMBL1706384 | — | IC50 | = | 10190.0 | nM | 4.99 |
| CHEMBL472882 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL3260873 | — | IC50 | = | 11550.0 | nM | 4.94 |
| CHEMBL481349 | — | IC50 | = | 11920.0 | nM | 4.92 |
| CHEMBL4160426 | — | IC50 | = | 13140.0 | nM | 4.88 |
| CHEMBL4164405 | — | IC50 | = | 14240.0 | nM | 4.85 |
| CHEMBL4172085 | — | IC50 | = | 15120.0 | nM | 4.82 |
| CHEMBL2413120 | — | IC50 | = | 20240.0 | nM | 4.69 |
| CHEMBL4160617 | — | IC50 | = | 26590.0 | nM | 4.58 |
| CHEMBL416237 | — | IC50 | = | 40640.0 | nM | 4.39 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 47910.0 | nM | 4.32 |
| CHEMBL4167659 | — | IC50 | = | 60610.0 | nM | 4.22 |
| CHEMBL521258 | — | IC50 | = | 85530.0 | nM | 4.07 |
| CHEMBL479592 | — | log1/IC50 | = | 5.06 | — | - |
| CHEMBL4165020 | — | log1/IC50 | = | 5.96 | — | - |
| CHEMBL4167006 | — | log1/IC50 | = | 5.09 | — | - |
| CHEMBL3415955 | — | log1/IC50 | = | 5.22 | — | - |
| CHEMBL3260876 | — | log1/IC50 | = | 5.14 | — | - |
| CHEMBL521258 | — | log1/IC50 | = | 4.07 | — | - |
| CHEMBL3260873 | — | log1/IC50 | = | 4.94 | — | - |
| CHEMBL416237 | — | log1/IC50 | = | 4.39 | — | - |
| CHEMBL4163560 | — | log1/IC50 | = | 5.12 | — | - |
| CHEMBL2413121 | — | log1/IC50 | = | 5.61 | — | - |