Assay Detail
Binding
CHEMBL4229764
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.69 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4250984 | — | — | 1 | 9.52 |
| CHEMBL4243296 | — | — | 1 | 8.96 |
| CHEMBL4240868 | — | — | 1 | 8.74 |
| CHEMBL303336 | — | — | 1 | 8.70 |
| CHEMBL4243361 | — | — | 1 | 8.57 |
| CHEMBL4247145 | — | — | 1 | 8.54 |
| CHEMBL302197 | — | — | 1 | 8.42 |
| CHEMBL62408 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4250984 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL4243296 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL4240868 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL303336 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4243361 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL4247145 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL302197 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL62408 | — | Ki | = | 8.0 | nM | 8.10 |