Compound Detail
CHEMBL4243296
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Basic Information
| ChEMBL ID | CHEMBL4243296 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TYJPHBPGOHKHLW-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
307.5
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 8.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 CHEMBL4153 | Ki | 8.96 | 8.96 | 1.1 | 2 |
| Sigma intracellular receptor 2 CHEMBL4105864 | Ki | 6.61 | 6.61 | 243.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 | Ki | = | 1.1 | nM | 8.96 | Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain me... | 29039662 |
| Sigma non-opioid intracellular receptor 1 | Ki | = | 1.1 | nM | 8.96 | Binding affinity to Guinea pig brain Sigma1 receptor assessed as inhibition cons... | 33381970 |
| Sigma intracellular receptor 2 | Ki | = | 243.0 | nM | 6.61 | Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 ... | 29039662 |
| Sigma intracellular receptor 2 | Ki | = | 243.0 | nM | 6.61 | Binding affinity to rat liver Sigma2 receptor assessed as inhibition constant | 33381970 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29039662 | 10.1021/acs.jmedchem.7b00718 | Sigma non-opioid intracellular receptor 1 | 1 |
| 29039662 | 10.1021/acs.jmedchem.7b00718 | Sigma intracellular receptor 2 | 1 |
| 29039662 | 10.1021/acs.jmedchem.7b00718 | Unchecked | 1 |
| 33381970 | 10.1021/acs.jmedchem.0c01473 | Sigma non-opioid intracellular receptor 1 | 1 |
| 33381970 | 10.1021/acs.jmedchem.0c01473 | Sigma intracellular receptor 2 | 1 |
| 33381970 | 10.1021/acs.jmedchem.0c01473 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine