Assay Detail
Binding
CHEMBL4229765
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma intracellular receptor 2 (CHEMBL4105864) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.23 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4240868 | — | — | 1 | 8.26 |
| CHEMBL4250984 | — | — | 1 | 7.72 |
| CHEMBL62408 | — | — | 1 | 7.47 |
| CHEMBL4247145 | — | — | 1 | 7.41 |
| CHEMBL303336 | — | — | 1 | 7.36 |
| CHEMBL302197 | — | — | 1 | 6.69 |
| CHEMBL4243296 | — | — | 1 | 6.61 |
| CHEMBL4243361 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4240868 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL4250984 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL62408 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL4247145 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL303336 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL302197 | — | Ki | = | 206.0 | nM | 6.69 |
| CHEMBL4243296 | — | Ki | = | 243.0 | nM | 6.61 |
| CHEMBL4243361 | — | Ki | = | 460.0 | nM | 6.34 |