Compound Detail
CHEMBL4243361
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4243361 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CRFDPZVUNDAAEN-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
337.5
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 CHEMBL4153 | Ki | 8.57 | 8.57 | 2.7 | 1 |
| Sigma intracellular receptor 2 CHEMBL4105864 | Ki | 6.34 | 6.34 | 460.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 | Ki | = | 2.7 | nM | 8.57 | Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain me... | 29039662 |
| Sigma intracellular receptor 2 | Ki | = | 460.0 | nM | 6.34 | Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 ... | 29039662 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29039662 | 10.1021/acs.jmedchem.7b00718 | Sigma non-opioid intracellular receptor 1 | 1 |
| 29039662 | 10.1021/acs.jmedchem.7b00718 | Sigma intracellular receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine