Compound Detail
CHEMBL4250984
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Basic Information
| ChEMBL ID | CHEMBL4250984 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DZORAYSBOIWZSY-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
287.5
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 9.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 CHEMBL4153 | Ki | 9.52 | 9.52 | 0.3 | 1 |
| Sigma intracellular receptor 2 CHEMBL4105864 | Ki | 7.72 | 7.72 | 19.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 | Ki | = | 0.3 | nM | 9.52 | Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain me... | 29039662 |
| Sigma intracellular receptor 2 | Ki | = | 19.0 | nM | 7.72 | Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 ... | 29039662 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29039662 | 10.1021/acs.jmedchem.7b00718 | Sigma non-opioid intracellular receptor 1 | 1 |
| 29039662 | 10.1021/acs.jmedchem.7b00718 | Sigma intracellular receptor 2 | 1 |
| 29039662 | 10.1021/acs.jmedchem.7b00718 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine