Assay Detail
Functional
CHEMBL4231099
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-parasitic activity against bloodstream trypomastigote stage of pentamidine/diminazene/melaminophenyl arsenical resistant Trypanosoma brucei B48 after 48 hrs by resazurin-based assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 5.67 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4249714 | — | — | 1 | 9.12 |
| CHEMBL4245918 | — | — | 1 | 8.72 |
| CHEMBL4250711 | — | — | 1 | 8.66 |
| CHEMBL4244022 | — | — | 1 | 7.05 |
| CHEMBL4247258 | — | — | 1 | 6.96 |
| CHEMBL4237349 | — | — | 1 | 6.52 |
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | 6.11 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 6.03 |
| CHEMBL4237238 | — | — | 1 | 5.63 |
| CHEMBL4240979 | — | — | 1 | 5.44 |
| CHEMBL4247810 | — | — | 1 | 5.35 |
| CHEMBL4239171 | — | — | 1 | 4.89 |
| CHEMBL4248268 | — | — | 1 | 4.84 |
| CHEMBL4090897 | — | — | 1 | 4.83 |
| CHEMBL4237726 | — | — | 1 | 4.81 |
| CHEMBL4250174 | — | — | 1 | 4.81 |
| CHEMBL4237659 | — | — | 1 | 4.76 |
| CHEMBL4251018 | — | — | 1 | 4.69 |
| CHEMBL4068891 | — | — | 1 | 4.66 |
| CHEMBL4244828 | — | — | 1 | 4.50 |
| CHEMBL4241091 | — | — | 1 | 4.47 |
| CHEMBL4245303 | — | — | 1 | 4.44 |
| CHEMBL4241528 | — | — | 1 | 4.38 |
| CHEMBL4069905 | — | — | 1 | 4.31 |
| CHEMBL4249095 | — | — | 1 | - |
| CHEMBL4241625 | — | — | 1 | - |
| CHEMBL4243481 | — | — | 1 | - |
| CHEMBL328910 | 2,4-DIHYDROXYBENZOIC ACID | — | 1 | - |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4249714 | — | EC50 | = | 0.75 | nM | 9.12 |
| CHEMBL4245918 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4250711 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4244022 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4247258 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4237349 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL35241 | DIMINAZENE | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL55 | PENTAMIDINE | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL4237238 | — | EC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL4240979 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4247810 | — | EC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL4239171 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4248268 | — | EC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL4090897 | — | EC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL4237726 | — | EC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL4250174 | — | EC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL4237659 | — | EC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL4251018 | — | EC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL4068891 | — | EC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL4244828 | — | EC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL4241091 | — | EC50 | = | 33600.0 | nM | 4.47 |
| CHEMBL4245303 | — | EC50 | = | 36600.0 | nM | 4.44 |
| CHEMBL4241528 | — | EC50 | = | 41600.0 | nM | 4.38 |
| CHEMBL4069905 | — | EC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL4249095 | — | EC50 | = | 400000.0 | nM | - |
| CHEMBL4241625 | — | EC50 | = | 400000.0 | nM | - |
| CHEMBL4243481 | — | EC50 | = | 400000.0 | nM | - |
| CHEMBL328910 | 2,4-DIHYDROXYBENZOIC ACID | EC50 | - | — | - | |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | EC50 | - | — | - |