Assay Detail
Binding
CHEMBL4276233
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated for 5 mins followed by pCMV-dR8.91 plasmid and ATP addition measured after 60 mins by ADP-Glo assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Probable global transcription activator SNF2L2 (CHEMBL2362979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.89 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4278436 | — | — | 1 | 8.30 |
| CHEMBL4294655 | — | — | 1 | 8.00 |
| CHEMBL4286757 | — | — | 1 | 7.48 |
| CHEMBL4290175 | — | — | 1 | 7.22 |
| CHEMBL4279505 | — | — | 1 | 6.96 |
| CHEMBL4281368 | — | — | 1 | 6.70 |
| CHEMBL4282784 | — | — | 1 | 6.01 |
| CHEMBL4290675 | — | — | 1 | 5.96 |
| CHEMBL4292870 | — | — | 1 | 5.42 |
| CHEMBL4295096 | — | — | 1 | - |
| CHEMBL4282980 | — | — | 1 | - |
| CHEMBL4293567 | — | — | 1 | - |
| CHEMBL4286345 | — | — | 1 | - |
| CHEMBL4291666 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4278436 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4294655 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4286757 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4290175 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4279505 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4281368 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4282784 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4290675 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4292870 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4295096 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL4282980 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL4293567 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL4286345 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL4291666 | — | IC50 | > | 50000.0 | nM | - |