Assay Detail
Functional
CHEMBL4340263
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma cruzi Y trypomastigotes infected in LLC-MK2-ATCC CCL7 cells assessed as reduction in parasite growth incubated for 24 hrs by Alamar blue dye based assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship study of antitrypanosomal chalcone derivatives using multivariate analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 37 | 4.63 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2237021 | — | — | 1 | 5.48 |
| CHEMBL4460391 | — | — | 1 | 4.97 |
| CHEMBL286151 | — | — | 1 | 4.86 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 4.78 |
| CHEMBL61592 | — | — | 1 | 4.74 |
| CHEMBL4544160 | — | — | 1 | 4.72 |
| CHEMBL2282149 | — | — | 1 | 4.58 |
| CHEMBL4556196 | — | — | 1 | 4.58 |
| CHEMBL7976 | CHALCONE | — | 1 | 4.57 |
| CHEMBL4585757 | — | — | 1 | 4.55 |
| CHEMBL32147 | 2'-HYDROXYCHALCONE | — | 1 | 4.54 |
| CHEMBL4594015 | — | — | 1 | 4.54 |
| CHEMBL227747 | — | — | 1 | 4.22 |
| CHEMBL227400 | — | — | 1 | 4.21 |
| CHEMBL390381 | — | — | 1 | 4.13 |
| CHEMBL499801 | — | — | 1 | - |
| CHEMBL244458 | — | — | 1 | - |
| CHEMBL2237020 | — | — | 1 | - |
| CHEMBL489719 | — | — | 1 | - |
| CHEMBL455453 | — | — | 1 | - |
| CHEMBL490143 | DIHYDROCHALCONE | — | 1 | - |
| CHEMBL4443589 | — | — | 1 | - |
| CHEMBL4436635 | — | — | 1 | - |
| CHEMBL4435072 | — | — | 1 | - |
| CHEMBL4546900 | — | — | 1 | - |
| CHEMBL4521741 | — | — | 1 | - |
| CHEMBL4589355 | — | — | 1 | - |
| CHEMBL4576755 | — | — | 1 | - |
| CHEMBL4522833 | — | — | 1 | - |
| CHEMBL2012143 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2237021 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4460391 | — | EC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL286151 | — | EC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL110 | BENZNIDAZOLE | EC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL61592 | — | EC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL4544160 | — | EC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL2282149 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4556196 | — | EC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL7976 | CHALCONE | EC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL4585757 | — | EC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL4594015 | — | EC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL32147 | 2'-HYDROXYCHALCONE | EC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL227747 | — | EC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL227400 | — | EC50 | = | 60900.0 | nM | 4.21 |
| CHEMBL390381 | — | EC50 | = | 73200.0 | nM | 4.13 |
| CHEMBL34398 | 4'-METHOXYCHALCONE | EC50 | > | 100000.0 | nM | - |
| CHEMBL2237025 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL142840 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL242946 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2236854 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL224690 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2237017 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL499801 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL244458 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2237020 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL489719 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL455453 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL490143 | DIHYDROCHALCONE | EC50 | > | 100000.0 | nM | - |
| CHEMBL4443589 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4436635 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4435072 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4546900 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4521741 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4589355 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4576755 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4522833 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2012143 | — | EC50 | > | 100000.0 | nM | - |