Assay Detail
Binding
CHEMBL4340708
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-incubated for 5 mins before 2OG as substrate and Fe2 as co-factor addition in presence of L-ascorbate and measured after 5 mins MALDI TOF MS analysis
35
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Paramecium bursaria Chlorella virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prolyl 4-hydroxylase (CHEMBL4523368) ↗| Type | SINGLE PROTEIN |
| Organism | Paramecium bursaria Chlorella virus 1 |
Publication
Inhibition of a viral prolyl hydroxylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.97 | 5.60 |
| Ki | 7 | 5.48 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3646221 | VADADUSTAT | 4.0 | 2 | 6.55 |
| CHEMBL426560 | — | — | 2 | 6.15 |
| CHEMBL2338329 | ROXADUSTAT | 4.0 | 2 | 5.97 |
| CHEMBL3646117 | — | — | 1 | 5.60 |
| CHEMBL316034 | — | — | 2 | 5.48 |
| CHEMBL4163812 | — | — | 2 | 5.12 |
| CHEMBL3186774 | — | — | 1 | 5.07 |
| CHEMBL4475458 | — | — | 1 | 4.80 |
| CHEMBL3188597 | — | — | 1 | 4.80 |
| CHEMBL3646118 | MOLIDUSTAT | 2.0 | 2 | 4.79 |
| CHEMBL90852 | N-OXALYLGLYCINE | — | 2 | 4.67 |
| CHEMBL1230640 | — | — | 1 | 4.33 |
| CHEMBL2164243 | — | — | 1 | - |
| CHEMBL3785984 | — | — | 1 | - |
| CHEMBL4449628 | — | — | 1 | - |
| CHEMBL4540977 | — | — | 1 | - |
| CHEMBL3785164 | — | — | 1 | - |
| CHEMBL347285 | — | — | 1 | - |
| CHEMBL1261 | CITRIC ACID | 4.0 | 1 | - |
| CHEMBL390356 | ISOCITRIC ACID | — | 1 | - |
| CHEMBL503160 | FUMARIC ACID | 3.0 | 1 | - |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | - |
| CHEMBL1234046 | — | — | 1 | - |
| CHEMBL576 | SUCCINIC ACID | 3.0 | 1 | - |
| CHEMBL1615211 | — | — | 1 | - |
| CHEMBL1614745 | — | — | 1 | - |
| CHEMBL1794791 | OXALOACETATE | 2.0 | 1 | - |
| CHEMBL1162144 | PYRUVATE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3646221 | VADADUSTAT | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL426560 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL2338329 | ROXADUSTAT | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL3646117 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL316034 | — | Ki | = | 3280.0 | nM | 5.48 |
| CHEMBL426560 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL2338329 | ROXADUSTAT | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL316034 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4163812 | — | Ki | = | 7650.0 | nM | 5.12 |
| CHEMBL3186774 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4163812 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL3188597 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL4475458 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL3646118 | MOLIDUSTAT | Ki | = | 16050.0 | nM | 4.79 |
| CHEMBL90852 | N-OXALYLGLYCINE | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL3646118 | MOLIDUSTAT | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL1230640 | — | IC50 | = | 47200.0 | nM | 4.33 |
| CHEMBL90852 | N-OXALYLGLYCINE | Ki | = | 48740.0 | nM | 4.31 |
| CHEMBL503160 | FUMARIC ACID | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2164243 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3785984 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4449628 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4540977 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3785164 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3646221 | VADADUSTAT | IC50 | < | 1000.0 | nM | - |
| CHEMBL1261 | CITRIC ACID | IC50 | = | 212600.0 | nM | - |
| CHEMBL390356 | ISOCITRIC ACID | IC50 | = | 284000.0 | nM | - |
| CHEMBL347285 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL575060 | GLUTAMIC ACID | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1234046 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1794791 | OXALOACETATE | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1162144 | PYRUVATE | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1614745 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL1615211 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL576 | SUCCINIC ACID | IC50 | > | 1000000.0 | nM | - |