Assay Detail
Binding
CHEMBL4351310
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CGP39653 from NMDA receptor in rat brain synaptic cortical membranes after 60 mins by scintillation counting method
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.22 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.70 |
| CHEMBL291278 | N-METHYL-D-ASPARTIC ACID (NMDA) | 2.0 | 1 | 5.21 |
| CHEMBL4444367 | — | — | 2 | 4.49 |
| CHEMBL4451018 | — | — | 1 | - |
| CHEMBL4448290 | — | — | 1 | - |
| CHEMBL4556711 | — | — | 1 | - |
| CHEMBL4529665 | — | — | 1 | - |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL291278 | N-METHYL-D-ASPARTIC ACID (NMDA) | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL4444367 | — | Ki | = | 32359.37 | nM | 4.49 |
| CHEMBL4444367 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL4451018 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4448290 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4556711 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4529665 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL275040 | KAINIC ACID | Ki | > | 100000.0 | nM | - |