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Assay Detail

CHEMBL4402048

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess reagent-based assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type RAW264.7
Confidence 1 — Organism
Curated By Autocuration

Target

RAW264.7 (CHEMBL612557)
Type CELL-LINE
Organism Mus musculus

Publication

Isolation, structural elucidation, and insights into the anti-inflammatory effects of triterpene saponins from the leaves of Stauntonia hexaphylla.
Vinh LB, Jang HJ, Phong NV, Cho K, Park SS, Kang JS, Kim YH, Yang SY.
Bioorg Med Chem Lett (2019) 29 : 965 -969
PubMed 30808589 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 5.91 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL384467 DEXAMETHASONE 4.0 1 6.89
CHEMBL444941 HEDERACOLCHISIDE A1 1 6.23
CHEMBL540220 1 5.74
CHEMBL4584478 1 4.78
CHEMBL538919 CAULOSIDE D 1 -
CHEMBL4451307 1 -
CHEMBL1171448 CIRENSENOSIDE O 1 -
CHEMBL4483520 1 -
CHEMBL510111 1 -
CHEMBL4542295 1 -
CHEMBL4557043 1 -
CHEMBL4519950 1 -
CHEMBL4469968 1 -
CHEMBL1910844 DIPSACUSSAPONIN A 1 -
CHEMBL4521246 1 -
CHEMBL1910840 KALOPANAXSAPONIN B 1 -
CHEMBL4441424 1 -
CHEMBL4447568 1 -
CHEMBL4463280 1 -
CHEMBL4455294 1 -
CHEMBL540943 KIZUTA CIRENSENOSIDE O SAPONIN K3 1 -
CHEMBL4579749 1 -
CHEMBL4443030 1 -
CHEMBL4465186 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL384467 DEXAMETHASONE IC50 = 130.0 nM 6.89
CHEMBL444941 HEDERACOLCHISIDE A1 IC50 = 590.0 nM 6.23
CHEMBL540220 IC50 = 1820.0 nM 5.74
CHEMBL4584478 IC50 = 16650.0 nM 4.78
CHEMBL538919 CAULOSIDE D IC50 > 50000.0 nM -
CHEMBL4451307 IC50 > 50000.0 nM -
CHEMBL1171448 CIRENSENOSIDE O IC50 > 50000.0 nM -
CHEMBL4483520 IC50 > 50000.0 nM -
CHEMBL510111 IC50 > 50000.0 nM -
CHEMBL4542295 IC50 > 50000.0 nM -
CHEMBL4557043 IC50 > 50000.0 nM -
CHEMBL4519950 IC50 > 50000.0 nM -
CHEMBL4469968 IC50 > 50000.0 nM -
CHEMBL1910844 DIPSACUSSAPONIN A IC50 > 50000.0 nM -
CHEMBL4521246 IC50 > 50000.0 nM -
CHEMBL1910840 KALOPANAXSAPONIN B IC50 > 50000.0 nM -
CHEMBL4441424 IC50 > 50000.0 nM -
CHEMBL4447568 IC50 > 50000.0 nM -
CHEMBL4463280 IC50 > 50000.0 nM -
CHEMBL4455294 IC50 > 50000.0 nM -
CHEMBL540943 KIZUTA CIRENSENOSIDE O SAPONIN K3 IC50 > 50000.0 nM -
CHEMBL4579749 IC50 > 50000.0 nM -
CHEMBL4443030 IC50 > 50000.0 nM -
CHEMBL4465186 IC50 > 50000.0 nM -