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Assay Detail

CHEMBL4407663

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Trypanocidal activity against Trypanosoma cruzi Y strain bloodstream trypomastigotes after 24 hrs
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones.
da Silva Júnior EN, Jardim GAM, Jacob C, Dhawa U, Ackermann L, de Castro SL.
Eur J Med Chem (2019) 179 : 863 -915
PubMed 31306817 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.61 6.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4166151 1 6.66
CHEMBL4165449 1 6.31
CHEMBL4160933 1 6.25
CHEMBL4174070 1 6.23
CHEMBL4161242 1 5.93
CHEMBL4169275 1 5.86
CHEMBL4168732 1 5.79
CHEMBL4168874 1 5.79
CHEMBL4175198 1 5.65
CHEMBL4177434 1 5.45
CHEMBL4166794 1 5.14
CHEMBL4439230 1 5.12
CHEMBL110 BENZNIDAZOLE 4.0 1 5.01
CHEMBL4162710 1 4.61
CHEMBL4170637 1 4.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4166151 IC50 = 220.0 nM 6.66
CHEMBL4165449 IC50 = 490.0 nM 6.31
CHEMBL4160933 IC50 = 560.0 nM 6.25
CHEMBL4174070 IC50 = 590.0 nM 6.23
CHEMBL4161242 IC50 = 1170.0 nM 5.93
CHEMBL4169275 IC50 = 1380.0 nM 5.86
CHEMBL4168732 IC50 = 1620.0 nM 5.79
CHEMBL4168874 IC50 = 1610.0 nM 5.79
CHEMBL4175198 IC50 = 2250.0 nM 5.65
CHEMBL4177434 IC50 = 3540.0 nM 5.45
CHEMBL4166794 IC50 = 7260.0 nM 5.14
CHEMBL4439230 IC50 = 7570.0 nM 5.12
CHEMBL110 BENZNIDAZOLE IC50 = 9680.0 nM 5.01
CHEMBL4162710 IC50 = 24840.0 nM 4.61
CHEMBL4170637 IC50 = 42000.0 nM 4.38