Assay Detail
Functional
CHEMBL4628669
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Antiviral activity against Respiratory syncytial virus B infected in Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by microscopic analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human respiratory syncytial virus B |
| Cell Type | HEp-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational modifications, synthesis and biological evaluation of new potential antivirals for RSV designed to target the M2-1 protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.35 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4644024 | — | — | 1 | 5.89 |
| CHEMBL4644354 | — | — | 1 | 5.88 |
| CHEMBL4636739 | — | — | 1 | 5.66 |
| CHEMBL4647384 | — | — | 1 | 5.60 |
| CHEMBL3417243 | ALS-8112 | -1.0 | 1 | 5.58 |
| CHEMBL4636539 | — | — | 1 | 5.52 |
| CHEMBL4638954 | — | — | 1 | 5.52 |
| CHEMBL4639233 | — | — | 1 | 5.42 |
| CHEMBL4635259 | — | — | 1 | 5.41 |
| CHEMBL4646464 | — | — | 1 | 5.41 |
| CHEMBL4648291 | — | — | 1 | 5.40 |
| CHEMBL4634563 | — | — | 1 | 4.90 |
| CHEMBL4646622 | — | — | 1 | 4.69 |
| CHEMBL4645991 | — | — | 1 | 4.69 |
| CHEMBL4639558 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4644024 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4644354 | — | EC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4636739 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4647384 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3417243 | ALS-8112 | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4636539 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4638954 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4639233 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4635259 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4646464 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4648291 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4634563 | — | EC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL4646622 | — | EC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL4645991 | — | EC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL4639558 | — | EC50 | = | 24800.0 | nM | 4.61 |