Assay Detail
Binding
CHEMBL5137735
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Inhibition of PKM2 (unknown origin)
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 9 | - | - |
| IC50 | 6 | 5.49 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9470 | SHIKONIN | — | 1 | 6.10 |
| CHEMBL28457 | ALKANNIN | — | 1 | 6.05 |
| CHEMBL19612 | SPERMIDINE | 3.0 | 1 | 5.85 |
| CHEMBL214344 | — | — | 1 | 5.16 |
| CHEMBL32749 | FERULATE | -1.0 | 1 | 4.94 |
| CHEMBL1414 | SYRINGIC ACID | — | 1 | 4.86 |
| CHEMBL301523 | PHENYLALANINE | 3.0 | 1 | - |
| CHEMBL279597 | ALANINE | 3.0 | 1 | - |
| CHEMBL42336 | METHIONINE | 3.0 | 1 | - |
| CHEMBL54922 | PROLINE | 2.0 | 1 | - |
| CHEMBL54976 | TRYPTOPHAN | 4.0 | 1 | - |
| CHEMBL43068 | VALINE | 2.0 | 1 | - |
| CHEMBL1233584 | ISOLEUCINE | 2.0 | 1 | - |
| CHEMBL291747 | THREONINE | 2.0 | 1 | - |
| CHEMBL863 | CYSTEINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9470 | SHIKONIN | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL28457 | ALKANNIN | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL19612 | SPERMIDINE | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL214344 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL32749 | FERULATE | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL1414 | SYRINGIC ACID | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL301523 | PHENYLALANINE | Inhibition | = | 100.0 | % | - |
| CHEMBL279597 | ALANINE | Inhibition | = | 100.0 | % | - |
| CHEMBL42336 | METHIONINE | Inhibition | = | 65.0 | % | - |
| CHEMBL54922 | PROLINE | Inhibition | = | 65.0 | % | - |
| CHEMBL54976 | TRYPTOPHAN | Inhibition | = | 65.0 | % | - |
| CHEMBL43068 | VALINE | Inhibition | = | 65.0 | % | - |
| CHEMBL1233584 | ISOLEUCINE | Inhibition | = | 20.0 | % | - |
| CHEMBL291747 | THREONINE | Inhibition | = | 20.0 | % | - |
| CHEMBL863 | CYSTEINE | Inhibition | = | 20.0 | % | - |