Assay Detail
Functional
CHEMBL5231920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma cruzi ATCC CCL92 assessed as reduction in viable parasite measured after 48 hrs by Hoechst 33342 staining based microscopic analysis
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.51 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5204259 | — | — | 1 | 7.80 |
| CHEMBL5286789 | — | — | 1 | 7.37 |
| CHEMBL5267783 | — | — | 1 | 7.29 |
| CHEMBL5196011 | — | — | 1 | 7.19 |
| CHEMBL5286311 | — | — | 1 | 7.18 |
| CHEMBL5285054 | — | — | 1 | 7.14 |
| CHEMBL5284979 | — | — | 1 | 7.11 |
| CHEMBL5198173 | — | — | 1 | 7.06 |
| CHEMBL5201175 | — | — | 1 | 7.00 |
| CHEMBL5272020 | — | — | 1 | 6.92 |
| CHEMBL4580019 | — | — | 1 | 6.82 |
| CHEMBL5275269 | — | — | 1 | 6.80 |
| CHEMBL5277857 | — | — | 1 | 6.68 |
| CHEMBL5200784 | — | — | 1 | 6.64 |
| CHEMBL5178306 | — | — | 1 | 6.37 |
| CHEMBL5283670 | — | — | 1 | 6.27 |
| CHEMBL5276646 | — | — | 1 | 6.05 |
| CHEMBL5285887 | — | — | 1 | 5.89 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.85 |
| CHEMBL5284681 | — | — | 1 | 5.82 |
| CHEMBL5269176 | — | — | 1 | 5.64 |
| CHEMBL469912 | PUROMYCIN | 2.0 | 1 | 5.60 |
| CHEMBL4473101 | — | — | 1 | 5.54 |
| CHEMBL5273984 | — | — | 1 | 5.33 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.28 |
| CHEMBL5283189 | — | — | 1 | - |
| CHEMBL4453399 | — | — | 1 | - |
| CHEMBL4457433 | — | — | 1 | - |
| CHEMBL5271296 | — | — | 1 | - |
| CHEMBL5275723 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5204259 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5286789 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5267783 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5196011 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5286311 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5285054 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5284979 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL5198173 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL5201175 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5272020 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4580019 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5275269 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5277857 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5200784 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5178306 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5283670 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5276646 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5285887 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5284681 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5269176 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL469912 | PUROMYCIN | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4473101 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5273984 | — | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5290957 | — | IC50 | - | — | - | |
| CHEMBL5092469 | — | IC50 | - | — | - | |
| CHEMBL5279241 | — | IC50 | - | — | - | |
| CHEMBL5290393 | — | IC50 | - | — | - | |
| CHEMBL5280228 | — | IC50 | - | — | - | |
| CHEMBL5269704 | — | IC50 | - | — | - | |
| CHEMBL5282691 | — | IC50 | - | — | - | |
| CHEMBL5279016 | — | IC50 | - | — | - | |
| CHEMBL4592098 | — | IC50 | - | — | - | |
| CHEMBL4476005 | — | IC50 | - | — | - | |
| CHEMBL5266915 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5272514 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5275723 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5271296 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4457433 | — | IC50 | - | — | - | |
| CHEMBL4453399 | — | IC50 | - | — | - | |
| CHEMBL5283189 | — | IC50 | - | — | - |