Assay Detail
Binding
CHEMBL5342458
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CSF1R (530 to 910 residues) (unknown origin)
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Development of Highly Selective Pyrrolo[2,3-<i>d</i>]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 8.57 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5432649 | — | — | 1 | 9.52 |
| CHEMBL5434318 | — | — | 1 | 9.52 |
| CHEMBL5417607 | — | — | 1 | 9.40 |
| CHEMBL5428404 | — | — | 1 | 9.30 |
| CHEMBL5406924 | — | — | 1 | 9.30 |
| CHEMBL5417494 | — | — | 1 | 9.15 |
| CHEMBL5406771 | — | — | 1 | 9.10 |
| CHEMBL5422465 | — | — | 1 | 9.10 |
| CHEMBL5431583 | — | — | 1 | 9.00 |
| CHEMBL5424694 | — | — | 1 | 9.00 |
| CHEMBL5403478 | — | — | 1 | 8.96 |
| CHEMBL5395449 | — | — | 1 | 8.92 |
| CHEMBL5411378 | — | — | 1 | 8.89 |
| CHEMBL5440766 | — | — | 1 | 8.77 |
| CHEMBL5439547 | — | — | 1 | 8.70 |
| CHEMBL5432592 | — | — | 1 | 8.68 |
| CHEMBL5414964 | — | — | 1 | 8.62 |
| CHEMBL5426924 | — | — | 1 | 8.60 |
| CHEMBL5406951 | — | — | 1 | 8.55 |
| CHEMBL5436096 | — | — | 1 | 8.55 |
| CHEMBL5417945 | — | — | 1 | 8.55 |
| CHEMBL5418474 | — | — | 1 | 8.43 |
| CHEMBL5438430 | — | — | 1 | 8.43 |
| CHEMBL5411522 | — | — | 1 | 8.28 |
| CHEMBL5418732 | — | — | 1 | 8.21 |
| CHEMBL5397557 | — | — | 1 | 8.08 |
| CHEMBL3813873 | PEXIDARTINIB | 4.0 | 1 | 8.01 |
| CHEMBL5403510 | — | — | 1 | 7.92 |
| CHEMBL5405639 | — | — | 1 | 7.82 |
| CHEMBL5398307 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5432649 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5434318 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5417607 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5428404 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5406924 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5417494 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5406771 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5422465 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5431583 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5424694 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5403478 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5395449 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5411378 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5440766 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5439547 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5432592 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5414964 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5426924 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5406951 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5436096 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5417945 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5418474 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5438430 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5411522 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL5418732 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5397557 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL3813873 | PEXIDARTINIB | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL5403510 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5405639 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5398307 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5419520 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL5431339 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5398686 | — | IC50 | < | 0.3 | nM | - |
| CHEMBL5404799 | — | IC50 | > | 100.0 | nM | - |