Compound Detail
CHEMBL5406771
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Basic Information
| ChEMBL ID | CHEMBL5406771 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CNWFAPYYHZIFRD-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
476.6
MW (Da)
4.32
ALogP
7
HBA
1
HBD
81.7
PSA (Ų)
0.27
QED
0
Ro5 Violations
14
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 9.1 | 9.1 | 0.8 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 7.35 | 7.35 | 45.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 0.8 | nM | 9.1 | Inhibition of CSF1R (530 to 910 residues) (unknown origin) | 37191268 |
| Epidermal growth factor receptor | IC50 | = | 45.0 | nM | 7.35 | Inhibition of EGFR (unknown origin) | 37191268 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37191268 | 10.1021/acs.jmedchem.3c00428 | Macrophage colony-stimulating factor 1 receptor | 1 |
| 37191268 | 10.1021/acs.jmedchem.3c00428 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine