Assay Detail
Binding
CHEMBL5342459
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Inhibition of EGFR (unknown origin)
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Development of Highly Selective Pyrrolo[2,3-<i>d</i>]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.79 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5403510 | — | — | 1 | 9.52 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 9.40 |
| CHEMBL5418732 | — | — | 1 | 9.10 |
| CHEMBL5397557 | — | — | 1 | 9.00 |
| CHEMBL5417607 | — | — | 1 | 8.70 |
| CHEMBL5406951 | — | — | 1 | 8.43 |
| CHEMBL5404799 | — | — | 1 | 8.35 |
| CHEMBL5417494 | — | — | 1 | 8.13 |
| CHEMBL5398686 | — | — | 1 | 7.77 |
| CHEMBL5422465 | — | — | 1 | 7.75 |
| CHEMBL5431583 | — | — | 1 | 7.70 |
| CHEMBL5440766 | — | — | 1 | 7.66 |
| CHEMBL5436096 | — | — | 1 | 7.64 |
| CHEMBL5406771 | — | — | 1 | 7.35 |
| CHEMBL5434318 | — | — | 1 | 7.35 |
| CHEMBL5418474 | — | — | 1 | 7.33 |
| CHEMBL5414964 | — | — | 1 | 7.30 |
| CHEMBL5432592 | — | — | 1 | 7.28 |
| CHEMBL5419520 | — | — | 1 | 7.19 |
| CHEMBL5439547 | — | — | 1 | 7.17 |
| CHEMBL5411378 | — | — | 1 | 7.14 |
| CHEMBL5428404 | — | — | 1 | 7.11 |
| CHEMBL5406924 | — | — | 1 | 6.88 |
| CHEMBL5403478 | — | — | 1 | 6.88 |
| CHEMBL5424694 | — | — | 1 | 6.63 |
| CHEMBL5425966 | — | — | 1 | - |
| CHEMBL5395449 | — | — | 1 | - |
| CHEMBL5426924 | — | — | 1 | - |
| CHEMBL5398307 | — | — | 1 | - |
| CHEMBL5405639 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5403510 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5418732 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5397557 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5417607 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5406951 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5404799 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL5417494 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL5398686 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5422465 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5431583 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5440766 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5436096 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5406771 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5434318 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5418474 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5414964 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5432592 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5419520 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5439547 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5411378 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5428404 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5406924 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL5403478 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL5424694 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL5425966 | — | IC50 | - | — | - | |
| CHEMBL5395449 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5426924 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5398307 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5405639 | — | IC50 | > | 100.0 | nM | - |