Compound Detail
CHEMBL5403510
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Basic Information
| ChEMBL ID | CHEMBL5403510 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JFFNMSINEFWPKX-CQSZACIVSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
344.4
MW (Da)
4.29
ALogP
4
HBA
3
HBD
73.8
PSA (Ų)
0.50
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 9.52 | 9.52 | 0.3 | 1 |
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 7.94 | 7.93 | 11.6 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 0.3 | nM | 9.52 | Inhibition of EGFR (unknown origin) | 37191268 |
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 11.6 | nM | 7.94 | Inhibition of CSF1R (unknown origin) using FRET-peptide as substrate incubated i... | 37141705 |
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 12.0 | nM | 7.92 | Inhibition of CSF1R (530 to 910 residues) (unknown origin) | 37191268 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37141705 | 10.1016/j.ejmech.2023.115344 | Macrophage colony-stimulating factor 1 receptor | 1 |
| 37191268 | 10.1021/acs.jmedchem.3c00428 | Macrophage colony-stimulating factor 1 receptor | 1 |
| 37191268 | 10.1021/acs.jmedchem.3c00428 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine