Assay Detail
Toxicity
CHEMBL5355751
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Cytotoxicity against human THP-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and in vitro antileishmanial activity of alkylene-linked nitrofurantoin-triazole hybrids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.47 | 5.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5427246 | — | — | 1 | 5.18 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 4.83 |
| CHEMBL5410890 | — | — | 1 | 4.42 |
| CHEMBL5415247 | — | — | 1 | 4.30 |
| CHEMBL5418015 | — | — | 1 | 4.28 |
| CHEMBL5398253 | — | — | 1 | 4.16 |
| CHEMBL351937 | — | — | 1 | 4.09 |
| CHEMBL572 | NITROFURANTOIN | 4.0 | 1 | - |
| CHEMBL5402237 | — | — | 1 | - |
| CHEMBL5432685 | — | — | 1 | - |
| CHEMBL1103 | FURAZOLIDONE | 4.0 | 1 | - |
| CHEMBL869 | NITROFURAZONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5427246 | — | IC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 14860.0 | nM | 4.83 |
| CHEMBL5410890 | — | IC50 | = | 38470.0 | nM | 4.42 |
| CHEMBL5415247 | — | IC50 | = | 50640.0 | nM | 4.30 |
| CHEMBL5418015 | — | IC50 | = | 52470.0 | nM | 4.28 |
| CHEMBL5398253 | — | IC50 | = | 69960.0 | nM | 4.16 |
| CHEMBL351937 | — | IC50 | = | 80920.0 | nM | 4.09 |
| CHEMBL572 | NITROFURANTOIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL5402237 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5432685 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1103 | FURAZOLIDONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL869 | NITROFURAZONE | IC50 | > | 100000.0 | nM | - |