Assay Detail
Binding
CHEMBL617633
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The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2,3-dihydro and carbocyclic analogues of tryptamines: interaction with serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 15 | 5.83 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 7.08 |
| CHEMBL352140 | — | — | 1 | 6.74 |
| CHEMBL6640 | TRYPTAMINE | — | 1 | 6.27 |
| CHEMBL138614 | — | — | 1 | 6.02 |
| CHEMBL12420 | N,N-DIMETHYLTRYPTAMINE | 2.0 | 1 | 6.00 |
| CHEMBL348588 | — | — | 1 | 5.97 |
| CHEMBL159503 | — | — | 1 | 5.68 |
| CHEMBL161241 | — | — | 1 | 5.68 |
| CHEMBL161751 | — | — | 2 | 5.66 |
| CHEMBL30294 | — | — | 1 | 5.61 |
| CHEMBL159346 | — | — | 1 | 5.60 |
| CHEMBL159689 | — | — | 1 | 5.34 |
| CHEMBL50115 | — | — | 1 | 5.32 |
| CHEMBL289199 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7257 | MEBUFOTENIN | Kd | = | 83.18 | nM | 7.08 |
| CHEMBL352140 | — | Kd | = | 181.97 | nM | 6.74 |
| CHEMBL6640 | TRYPTAMINE | Kd | = | 537.03 | nM | 6.27 |
| CHEMBL138614 | — | Kd | = | 954.99 | nM | 6.02 |
| CHEMBL12420 | N,N-DIMETHYLTRYPTAMINE | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL348588 | — | Kd | = | 1071.52 | nM | 5.97 |
| CHEMBL159503 | — | Kd | = | 2089.3 | nM | 5.68 |
| CHEMBL161241 | — | Kd | = | 2089.3 | nM | 5.68 |
| CHEMBL161751 | — | Kd | = | 2187.76 | nM | 5.66 |
| CHEMBL30294 | — | Kd | = | 2454.71 | nM | 5.61 |
| CHEMBL159346 | — | Kd | = | 2511.89 | nM | 5.60 |
| CHEMBL161751 | — | Kd | = | 4265.8 | nM | 5.37 |
| CHEMBL159689 | — | Kd | = | 4570.88 | nM | 5.34 |
| CHEMBL50115 | — | Kd | = | 4786.3 | nM | 5.32 |
| CHEMBL289199 | — | Kd | = | 8128.31 | nM | 5.09 |