Assay Detail
Binding
CHEMBL638449
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Inhibitory concentration against acetylcholinesterase from human erythrocytes
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.01 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176521 | — | — | 1 | 8.09 |
| CHEMBL174046 | — | — | 1 | 7.93 |
| CHEMBL173018 | — | — | 1 | 7.92 |
| CHEMBL609977 | — | — | 1 | 7.91 |
| CHEMBL173607 | — | — | 1 | 7.78 |
| CHEMBL263785 | — | — | 1 | 7.76 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.75 |
| CHEMBL143055 | — | — | 1 | 7.74 |
| CHEMBL173309 | — | — | 1 | 7.73 |
| CHEMBL173935 | — | — | 1 | 7.71 |
| CHEMBL368075 | — | — | 1 | 7.47 |
| CHEMBL137059 | — | — | 1 | 7.43 |
| CHEMBL176585 | — | — | 1 | 7.31 |
| CHEMBL174228 | — | — | 1 | 7.25 |
| CHEMBL174710 | — | — | 1 | 7.14 |
| CHEMBL172442 | — | — | 1 | 7.11 |
| CHEMBL177052 | — | — | 1 | 6.95 |
| CHEMBL11805 | CAPROCTAMINE | — | 1 | 6.77 |
| CHEMBL175047 | — | — | 1 | 6.69 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.60 |
| CHEMBL176773 | — | — | 1 | 6.17 |
| CHEMBL176308 | — | — | 1 | 6.10 |
| CHEMBL173136 | — | — | 1 | 5.34 |
| CHEMBL27673 | METHOCTRAMINE | — | 1 | 5.27 |
| CHEMBL79012 | — | — | 1 | 5.24 |
| CHEMBL19060 | BENEXTRAMINE | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176521 | — | IC50 | = | 8.128 | nM | 8.09 |
| CHEMBL174046 | — | IC50 | = | 11.75 | nM | 7.93 |
| CHEMBL173018 | — | IC50 | = | 12.02 | nM | 7.92 |
| CHEMBL609977 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL173607 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL263785 | — | IC50 | = | 17.38 | nM | 7.76 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 17.78 | nM | 7.75 |
| CHEMBL143055 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL173309 | — | IC50 | = | 18.62 | nM | 7.73 |
| CHEMBL173935 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL368075 | — | IC50 | = | 33.88 | nM | 7.47 |
| CHEMBL137059 | — | IC50 | = | 37.15 | nM | 7.43 |
| CHEMBL176585 | — | IC50 | = | 48.98 | nM | 7.31 |
| CHEMBL174228 | — | IC50 | = | 56.23 | nM | 7.25 |
| CHEMBL174710 | — | IC50 | = | 72.44 | nM | 7.14 |
| CHEMBL172442 | — | IC50 | = | 77.62 | nM | 7.11 |
| CHEMBL177052 | — | IC50 | = | 112.2 | nM | 6.95 |
| CHEMBL11805 | CAPROCTAMINE | IC50 | = | 169.82 | nM | 6.77 |
| CHEMBL175047 | — | IC50 | = | 204.17 | nM | 6.69 |
| CHEMBL95 | TACRINE | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL176773 | — | IC50 | = | 676.08 | nM | 6.17 |
| CHEMBL176308 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL173136 | — | IC50 | = | 4570.88 | nM | 5.34 |
| CHEMBL27673 | METHOCTRAMINE | IC50 | = | 5370.32 | nM | 5.27 |
| CHEMBL79012 | — | IC50 | = | 5754.4 | nM | 5.24 |
| CHEMBL19060 | BENEXTRAMINE | IC50 | = | 7244.36 | nM | 5.14 |