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Compound Detail

CHEMBL175047

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CCN(CCCCCCOCCCCCCCCOCCCCCCN(CC)Cc1ccccc1OC)Cc1ccccc1OC

Basic Information

ChEMBL ID CHEMBL175047
Phase Preclinical
Structure Type MOL
InChI Key IQTNXMOPVSCWJR-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

641.0
MW (Da)
9.54
ALogP
6
HBA
0
HBD
43.4
PSA (Ų)
0.08
QED
2
Ro5 Violations
31
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C40H68N2O4
MW 640.99
Aromatic Rings 2
Heavy Atoms 46
NP-Likeness -0.46

Activity Summary

IC50 2 meas. best 6.69

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Acetylcholinesterase
CHEMBL220
IC50 6.69 6.69 204.2 1
Cholinesterase
CHEMBL1914
IC50 5.58 5.58 2630.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
12620072 10.1021/jm021055+ Muscarinic acetylcholine receptor M2 2
12620072 10.1021/jm021055+ Acetylcholinesterase 1
12620072 10.1021/jm021055+ Cholinesterase 1
12620072 10.1021/jm021055+ Cholinesterases; ACHE & BCHE 1
12620072 10.1021/jm021055+ ADMET 1

Data from ChEMBL 36 via Core Engine