Assay Detail
Binding
CHEMBL655895
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Inhibitory concentration against butyrylcholinesterase from human serum
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.75 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.64 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.27 |
| CHEMBL263785 | — | — | 1 | 7.08 |
| CHEMBL368075 | — | — | 1 | 6.78 |
| CHEMBL172442 | — | — | 1 | 6.12 |
| CHEMBL174710 | — | — | 1 | 6.06 |
| CHEMBL27673 | METHOCTRAMINE | — | 1 | 6.01 |
| CHEMBL176585 | — | — | 1 | 5.97 |
| CHEMBL173018 | — | — | 1 | 5.85 |
| CHEMBL176521 | — | — | 1 | 5.78 |
| CHEMBL143055 | — | — | 1 | 5.67 |
| CHEMBL173309 | — | — | 1 | 5.65 |
| CHEMBL609977 | — | — | 1 | 5.62 |
| CHEMBL137059 | — | — | 1 | 5.60 |
| CHEMBL173935 | — | — | 1 | 5.59 |
| CHEMBL175047 | — | — | 1 | 5.58 |
| CHEMBL177052 | — | — | 1 | 5.39 |
| CHEMBL79012 | — | — | 1 | 5.26 |
| CHEMBL19060 | BENEXTRAMINE | — | 1 | 5.21 |
| CHEMBL173607 | — | — | 1 | 5.19 |
| CHEMBL174228 | — | — | 1 | 5.13 |
| CHEMBL174046 | — | — | 1 | 5.12 |
| CHEMBL176773 | — | — | 1 | 5.08 |
| CHEMBL11805 | CAPROCTAMINE | — | 1 | 4.93 |
| CHEMBL176308 | — | — | 1 | 4.26 |
| CHEMBL173136 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 22.91 | nM | 7.64 |
| CHEMBL95 | TACRINE | IC50 | = | 53.7 | nM | 7.27 |
| CHEMBL263785 | — | IC50 | = | 83.18 | nM | 7.08 |
| CHEMBL368075 | — | IC50 | = | 165.96 | nM | 6.78 |
| CHEMBL172442 | — | IC50 | = | 758.58 | nM | 6.12 |
| CHEMBL174710 | — | IC50 | = | 870.96 | nM | 6.06 |
| CHEMBL27673 | METHOCTRAMINE | IC50 | = | 977.24 | nM | 6.01 |
| CHEMBL176585 | — | IC50 | = | 1071.52 | nM | 5.97 |
| CHEMBL173018 | — | IC50 | = | 1412.54 | nM | 5.85 |
| CHEMBL176521 | — | IC50 | = | 1659.59 | nM | 5.78 |
| CHEMBL143055 | — | IC50 | = | 2137.96 | nM | 5.67 |
| CHEMBL173309 | — | IC50 | = | 2238.72 | nM | 5.65 |
| CHEMBL609977 | — | IC50 | = | 2398.83 | nM | 5.62 |
| CHEMBL137059 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL173935 | — | IC50 | = | 2570.4 | nM | 5.59 |
| CHEMBL175047 | — | IC50 | = | 2630.27 | nM | 5.58 |
| CHEMBL177052 | — | IC50 | = | 4073.8 | nM | 5.39 |
| CHEMBL79012 | — | IC50 | = | 5495.41 | nM | 5.26 |
| CHEMBL19060 | BENEXTRAMINE | IC50 | = | 6165.95 | nM | 5.21 |
| CHEMBL173607 | — | IC50 | = | 6456.54 | nM | 5.19 |
| CHEMBL174228 | — | IC50 | = | 7413.1 | nM | 5.13 |
| CHEMBL174046 | — | IC50 | = | 7585.78 | nM | 5.12 |
| CHEMBL176773 | — | IC50 | = | 8317.64 | nM | 5.08 |
| CHEMBL11805 | CAPROCTAMINE | IC50 | = | 11748.98 | nM | 4.93 |
| CHEMBL176308 | — | IC50 | = | 54954.09 | nM | 4.26 |
| CHEMBL173136 | — | IC50 | = | 165958.69 | nM | - |