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Compound Detail

CHEMBL174710

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COc1ccccc1CN(CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(Cc1ccccc1OC)C(C)C)C(C)C

Basic Information

ChEMBL ID CHEMBL174710
Phase Preclinical
Structure Type MOL
InChI Key HCMYZQSCTADARC-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

723.1
MW (Da)
9.20
ALogP
6
HBA
0
HBD
65.6
PSA (Ų)
0.08
QED
2
Ro5 Violations
29
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C44H74N4O4
MW 723.10
Aromatic Rings 2
Heavy Atoms 52
NP-Likeness -0.52

Activity Summary

IC50 2 meas. best 7.14

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Acetylcholinesterase
CHEMBL220
IC50 7.14 7.14 72.4 1
Cholinesterase
CHEMBL1914
IC50 6.06 6.06 871.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
12620072 10.1021/jm021055+ Muscarinic acetylcholine receptor M2 2
12620072 10.1021/jm021055+ Acetylcholinesterase 1
12620072 10.1021/jm021055+ Cholinesterase 1
12620072 10.1021/jm021055+ Cholinesterases; ACHE & BCHE 1
12620072 10.1021/jm021055+ ADMET 1

Data from ChEMBL 36 via Core Engine