Assay Detail
Binding
CHEMBL641409
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Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central alpha 2-antagonistic activity as potential antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.31 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL351483 | — | — | 1 | 9.02 |
| CHEMBL163247 | — | — | 1 | 8.90 |
| CHEMBL165350 | — | — | 1 | 8.87 |
| CHEMBL163190 | — | — | 1 | 8.83 |
| CHEMBL162370 | — | — | 1 | 8.81 |
| CHEMBL162826 | — | — | 1 | 8.76 |
| CHEMBL162147 | — | — | 1 | 8.71 |
| CHEMBL162490 | — | — | 1 | 8.69 |
| CHEMBL162682 | — | — | 1 | 8.68 |
| CHEMBL351200 | — | — | 1 | 8.67 |
| CHEMBL165796 | — | — | 1 | 8.59 |
| CHEMBL162501 | LUSAPERIDONE | 2.0 | 1 | 8.59 |
| CHEMBL162232 | — | — | 1 | 8.58 |
| CHEMBL162436 | — | — | 1 | 8.38 |
| CHEMBL164612 | — | — | 1 | 8.36 |
| CHEMBL165776 | — | — | 1 | 7.97 |
| CHEMBL165181 | — | — | 1 | 7.94 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 7.71 |
| CHEMBL165677 | — | — | 1 | 7.10 |
| CHEMBL162058 | — | — | 1 | 6.71 |
| CHEMBL654 | MIRTAZAPINE | 4.0 | 1 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL351483 | — | IC50 | = | 0.955 | nM | 9.02 |
| CHEMBL163247 | — | IC50 | = | 1.259 | nM | 8.90 |
| CHEMBL165350 | — | IC50 | = | 1.349 | nM | 8.87 |
| CHEMBL163190 | — | IC50 | = | 1.479 | nM | 8.83 |
| CHEMBL162370 | — | IC50 | = | 1.549 | nM | 8.81 |
| CHEMBL162826 | — | IC50 | = | 1.738 | nM | 8.76 |
| CHEMBL162147 | — | IC50 | = | 1.95 | nM | 8.71 |
| CHEMBL162490 | — | IC50 | = | 2.042 | nM | 8.69 |
| CHEMBL162682 | — | IC50 | = | 2.089 | nM | 8.68 |
| CHEMBL351200 | — | IC50 | = | 2.138 | nM | 8.67 |
| CHEMBL165796 | — | IC50 | = | 2.57 | nM | 8.59 |
| CHEMBL162501 | LUSAPERIDONE | IC50 | = | 2.57 | nM | 8.59 |
| CHEMBL162232 | — | IC50 | = | 2.63 | nM | 8.58 |
| CHEMBL162436 | — | IC50 | = | 4.169 | nM | 8.38 |
| CHEMBL164612 | — | IC50 | = | 4.365 | nM | 8.36 |
| CHEMBL165776 | — | IC50 | = | 10.72 | nM | 7.97 |
| CHEMBL165181 | — | IC50 | = | 11.48 | nM | 7.94 |
| CHEMBL10316 | IDAZOXAN | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL165677 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL162058 | — | IC50 | = | 194.98 | nM | 6.71 |
| CHEMBL654 | MIRTAZAPINE | IC50 | = | 223.87 | nM | 6.65 |