Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL351200

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
Cc1nc2c(C)cccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1

Basic Information

ChEMBL ID CHEMBL351200
Phase Preclinical
Structure Type MOL
InChI Key WLWNODXEXGTHDO-UHFFFAOYSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

373.5
MW (Da)
3.66
ALogP
5
HBA
0
HBD
50.8
PSA (Ų)
0.55
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H23N3O2
MW 373.46
Aromatic Rings 4
Heavy Atoms 28
NP-Likeness -1.26

Activity Summary

IC50 4 meas. best 9.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alpha-2A adrenergic receptor
CHEMBL1867
IC50 9.22 9.22 0.6 1
Alpha-2C adrenergic receptor
CHEMBL1916
IC50 8.88 8.88 1.3 1
Alpha-2B adrenergic receptor
CHEMBL1942
IC50 8.67 8.67 2.1 1
Alpha-1A adrenergic receptor
CHEMBL229
IC50 6.16 6.16 691.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10636247 10.1016/s0960-894x(99)00591-0 Rattus norvegicus 2
10636247 10.1016/s0960-894x(99)00591-0 Alpha-1A adrenergic receptor 1
10636247 10.1016/s0960-894x(99)00591-0 Alpha-2A adrenergic receptor 1
10636247 10.1016/s0960-894x(99)00591-0 Alpha-2B adrenergic receptor 1
10636247 10.1016/s0960-894x(99)00591-0 Alpha-2C adrenergic receptor 1

Data from ChEMBL 36 via Core Engine